Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Corynebacterium pseudotuberculosis (strain FRC41)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSE765874:GH5Y-1216-MONOMER.
UniPathwayiUPA00999; UER00351.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:cpfrc_01183
OrganismiCorynebacterium pseudotuberculosis (strain FRC41)
Taxonomic identifieri765874 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2432436-carboxyhexanoate--CoA ligasePRO_0000412083Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Family and domain databases

HAMAPiMF_00668. BioW. 1 hit.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8KN09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFYSVRMRA SLQGQHISGA ETLVSCPTDV PRLTAQFVER AMNHAKGVPD
60 70 80 90 100
AITTKIESIP ESDIQRVPRL LTREYQARDC HDAHGFVQQQ LTTVCSAEVA
110 120 130 140 150
QKAVDLLLTI RNMRGAILLD AHSARRLEPD HNRGIRASNF GDASSISAKP
160 170 180 190 200
DNKEIGISKN HYHEALILSS KVMSAPGIIA EICISDDPDY TTGYVSLNGV
210 220 230 240
YTRVHTMKRL GSPLGGRVFI LDSEKASVAT AINHIENTPV LIL
Length:243
Mass (Da):26,613
Last modified:October 5, 2010 - v1
Checksum:iC6EEB9E0EF72E527
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002097 Genomic DNA. Translation: ADK28976.1.
RefSeqiWP_013242038.1. NC_014329.1.

Genome annotation databases

EnsemblBacteriaiADK28976; ADK28976; cpfrc_01183.
GeneIDi12299610.
KEGGicpu:cpfrc_01183.
PATRICi42278396. VBICorPse165161_1237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002097 Genomic DNA. Translation: ADK28976.1.
RefSeqiWP_013242038.1. NC_014329.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK28976; ADK28976; cpfrc_01183.
GeneIDi12299610.
KEGGicpu:cpfrc_01183.
PATRICi42278396. VBICorPse165161_1237.

Phylogenomic databases

HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Enzyme and pathway databases

UniPathwayiUPA00999; UER00351.
BioCyciCPSE765874:GH5Y-1216-MONOMER.

Family and domain databases

HAMAPiMF_00668. BioW. 1 hit.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOW_CORPF
AccessioniPrimary (citable) accession number: D8KN09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 5, 2010
Last modified: November 11, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.