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D8KMW8 (D8KMW8_CORPF) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase HAMAP-Rule MF_00169
Short name=3-dehydroquinase HAMAP-Rule MF_00169
EC=4.2.1.10 HAMAP-Rule MF_00169
Alternative name(s):
Type II DHQase HAMAP-Rule MF_00169
Gene names
Name:aroQ HAMAP-Rule MF_00169
Ordered Locus Names:cpfrc_01142
OrganismCorynebacterium pseudotuberculosis (strain FRC41) [Complete proteome] [HAMAP]
Taxonomic identifier765874 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. SAAS SAAS001874 HAMAP-Rule MF_00169

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169

Subunit structure

Homododecamer By similarity. HAMAP-Rule MF_00169

Sequence similarities

Belongs to the type-II 3-dehydroquinase family. HAMAP-Rule MF_00169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region102 – 1032Substrate binding By similarity PIRSR PIRSR001399-2 HAMAP-Rule MF_00169

Sites

Active site221Proton acceptor By similarity PIRSR PIRSR001399-1 HAMAP-Rule MF_00169
Active site1011Proton donor By similarity PIRSR PIRSR001399-1 HAMAP-Rule MF_00169
Binding site731Substrate By similarity PIRSR PIRSR001399-2 HAMAP-Rule MF_00169
Binding site791Substrate By similarity PIRSR PIRSR001399-2 HAMAP-Rule MF_00169
Binding site861Substrate By similarity PIRSR PIRSR001399-2 HAMAP-Rule MF_00169
Binding site1121Substrate By similarity PIRSR PIRSR001399-2 HAMAP-Rule MF_00169
Site171Transition state stabilizer By similarity PIRSR PIRSR001399-5 HAMAP-Rule MF_00169

Sequences

Sequence LengthMass (Da)Tools
D8KMW8 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: E6A005177016548D

FASTA14615,967
        10         20         30         40         50         60 
MNILVLNGPN LDRLGKRQPE IYGRTTLADV EKLLVKRADA LGVTVIVKQS NYEGELIDWV 

        70         80         90        100        110        120 
HEAADAGWPV IINPGGLTHT SVSLRDALAE IHDGAGFVEV HISNIHAREE FRHHSFLSPI 

       130        140 
ARGVIAGLGV MGYELALEYL VLNSHS

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References

[1]"The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence."
Trost E., Ott L., Schneider J., Schroder J., Jaenicke S., Goesmann A., Husemann P., Stoye J., Alves Dorella F., Souza Rocha F., de Castro Soares S., D'Afonseca V., Miyoshi A., Ruiz J., Silva A., Azevedo V., Burkovski A., Guiso N. expand/collapse author list , Join-Lambert O.F., Kayal S., Tauch A.
BMC Genomics 11:728-728(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FRC41.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002097 Genomic DNA. Translation: ADK28935.1.
RefSeqYP_003783542.1. NC_014329.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADK28935; ADK28935; cpfrc_01142.
GeneID9449089.
KEGGcpu:cpfrc_01142.
PATRIC42278314. VBICorPse165161_1196.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000217278.
KOK03786.
OMARREPGHY.

Enzyme and pathway databases

BioCycCPSE765874:GH5Y-1175-MONOMER.
UniPathwayUPA00053; UER00086.

Family and domain databases

Gene3D3.40.50.9100. 1 hit.
HAMAPMF_00169. AroQ.
InterProIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERPTHR21272. PTHR21272. 1 hit.
PfamPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFPIRSF001399. DHquinase_II. 1 hit.
SUPFAMSSF52304. DHquinase_II. 1 hit.
TIGRFAMsTIGR01088. aroQ. 1 hit.
PROSITEPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8KMW8_CORPF
AccessionPrimary (citable) accession number: D8KMW8
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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