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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Corynebacterium pseudotuberculosis (strain FRC41)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481UniRule annotation
Active sitei592 – 5921UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciCPSE765874:GH5Y-1140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:cpfrc_01107Imported
OrganismiCorynebacterium pseudotuberculosis (strain FRC41)Imported
Taxonomic identifieri765874 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007092: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8KMT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKATSAGP LSEQLVEDIR FLGALLGEVI KEQEGIAAFD RVEAARQLAF
60 70 80 90 100
KISRKESQVE DLVALLKDIS AADAIPIIRA FSHFALLANM VEDLHDELGR
110 120 130 140 150
LQRQEAGEQD PDSTLGATWK KLANAGITNE KVSSLLSNFQ VAPVLTAHPT
160 170 180 190 200
ETRRRTIFDA QEHMTTLLKK RHAILSSETN ALTTARLEEN TRHIRRWLTL
210 220 230 240 250
IWQTALIRVA RPRIEDEVEV GLRYYELSLL TAIPEINKQV ADHIQREYGV
260 270 280 290 300
NSEDALQSLL IKPGSWIGGD HDGNPYVTAG TLHYATTRAA ETVLKFYVRE
310 320 330 340 350
LHQLEHELSL SDRLTDVSPD LRKLADLGHN DVPSRVDEPY RRAVHGVRGR
360 370 380 390 400
VLATLASRIG PETVEGSWYS RHAAYTAPEQ LAADLDIIDA SLRRTHDELI
410 420 430 440 450
ADDRLLRIRT AVSSFGFHLY SMDLRQNSES YEDVLTELFE RAQVTPHYRK
460 470 480 490 500
LDESEKISVL IAELSSPRPL IPRDGLPYSE LTQRELDIIF EAKQAVDAFG
510 520 530 540 550
TMMIPHSIIS MAESASDILE PMVLLKEFGL IKIQEGHLTG HIDVIPLFET
560 570 580 590 600
IDDLQNGAKI LQDLWQIPLY RSYLEQRGNL QEVMLGYSDS NKDGGYLAAN
610 620 630 640 650
WALYAAETDL VNICKQHGIA LRLFHGRGGT VGRGGGPSYE AILAQPHGAV
660 670 680 690 700
QGSVRVTEQG EIISAKYGSA GAARRNLEAL ASATLEASLL KIDQVEEQYP
710 720 730 740 750
EAYEIMGEIS RLSQKKYSRL AHEDPGFIEY FTSSTPLEEI GELNIGSRPS
760 770 780 790 800
SRKQTKSIDD LRAIPWVLSW SQSRVMLPGW YGVGSALHEW IEKGCAQTAE
810 820 830 840 850
LSPDERLVVL QELNSSWPFF SSVLSNMAQV MSKAEMQLAK LYSGLVADQE
860 870 880 890 900
AANRIFSDIS AEFELTKKMF LKITGFSGLL DDNPMLARSV RSRYPYLLPL
910 920 930
NTLQLEMLRR YRKGDDDPKV VHGIRLAMNG LATALRNSG
Length:939
Mass (Da):104,861
Last modified:October 5, 2010 - v1
Checksum:i29A44D32D3AA5121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002097 Genomic DNA. Translation: ADK28900.1.
RefSeqiWP_013241962.1. NC_014329.1.
YP_003783507.1. NC_014329.1.

Genome annotation databases

EnsemblBacteriaiADK28900; ADK28900; cpfrc_01107.
GeneIDi9449054.
KEGGicpu:cpfrc_01107.
PATRICi42278242. VBICorPse165161_1160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002097 Genomic DNA. Translation: ADK28900.1.
RefSeqiWP_013241962.1. NC_014329.1.
YP_003783507.1. NC_014329.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK28900; ADK28900; cpfrc_01107.
GeneIDi9449054.
KEGGicpu:cpfrc_01107.
PATRICi42278242. VBICorPse165161_1160.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.

Enzyme and pathway databases

BioCyciCPSE765874:GH5Y-1140-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence."
    Trost E., Ott L., Schneider J., Schroder J., Jaenicke S., Goesmann A., Husemann P., Stoye J., Dorella F.A., Rocha F.S., Soares Sde C., D'Afonseca V., Miyoshi A., Ruiz J., Silva A., Azevedo V., Burkovski A., Guiso N.
    , Join-Lambert O.F., Kayal S., Tauch A.
    BMC Genomics 11:728-728(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FRC41Imported.

Entry informationi

Entry nameiD8KMT3_CORPF
AccessioniPrimary (citable) accession number: D8KMT3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: March 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.