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Protein

Glutamate decarboxylase

Gene

LLNZ_06070

Organism
Lactococcus lactis subsp. cremoris (strain NZ9000)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciLLAC746361:GLFF-1201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:LLNZ_06070Imported
OrganismiLactococcus lactis subsp. cremoris (strain NZ9000)Imported
Taxonomic identifieri746361 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000007090: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD8KID3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

D8KID3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYGKENRDE AEFLEPIFGS ESEQVDLPKY KLAQQSIEPR VAYQLVQDEM
60 70 80 90 100
LDEGNARLNL ATFCQTYMEP EAVKLMSQTL EKNAIDKSEY PRTTEIENRC
110 120 130 140 150
VNMIADLWNA SEKEKFMGTS TIGSSEACML GGMAMKFSWR KRAEKLGLDI
160 170 180 190 200
NAKKPNLVIS SGYQVCWEKF CVYWDIEMRE VPMDREHMSI NLEKVMDYVD
210 220 230 240 250
EYTIGVVGIM GITYTGRYDD IKALDNLIEE YNKQTDYKVY IHVDAASGGL
260 270 280 290 300
YAPFVEPELE WDFRLKNVIS INTSGHKYGL VYPGVGWVLW RDKKYLPEEL
310 320 330 340 350
IFKVSYLGGE LPTMAINFSH SASQLIGQYY NFVRYGFDGY KAIHERTHKV
360 370 380 390 400
AMYLAEEIEK TGMFEIMNDG AQLPIVCYKL KENSNRGWNL YDLADRLLMK
410 420 430 440 450
GWQVPAYPLP KNLENEIIQR LVIRADFGMN MAFNYVQDMQ EAIDALNKAH
460
ILFHQEPENK TYGFTH
Length:466
Mass (Da):53,924
Last modified:October 5, 2010 - v1
Checksum:i668DB73A4DF40BF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002094 Genomic DNA. Translation: ADJ60179.1.
RefSeqiYP_006356601.1. NC_017949.1.

Genome annotation databases

EnsemblBacteriaiADJ60179; ADJ60179; LLNZ_06070.
GeneIDi13019826.
KEGGilln:LLNZ_06070.
PATRICi43095877. VBILacLac151604_1218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002094 Genomic DNA. Translation: ADJ60179.1.
RefSeqiYP_006356601.1. NC_017949.1.

3D structure databases

ProteinModelPortaliD8KID3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADJ60179; ADJ60179; LLNZ_06070.
GeneIDi13019826.
KEGGilln:LLNZ_06070.
PATRICi43095877. VBILacLac151604_1218.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.

Enzyme and pathway databases

BioCyciLLAC746361:GLFF-1201-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of Lactococcus lactis MG1363 (revised) and NZ9000 and comparative physiological studies."
    Linares D.M., Kok J., Poolman B.
    J. Bacteriol. 192:5806-5812(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NZ9000Imported.

Entry informationi

Entry nameiD8KID3_LACLN
AccessioniPrimary (citable) accession number: D8KID3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: February 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.