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D8KFQ1

- D8KFQ1_LACLN

UniProt

D8KFQ1 - D8KFQ1_LACLN

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Lactococcus lactis subsp. cremoris (strain NZ9000)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi289 – 2891Magnesium or manganese 1UniRule annotation
Metal bindingi302 – 3021Magnesium or manganese 1UniRule annotation
Metal bindingi302 – 3021Magnesium or manganese 2UniRule annotation
Metal bindingi304 – 3041Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 21756ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC746361:GLFF-377-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotationImported
Ordered Locus Names:LLNZ_01885Imported
OrganismiLactococcus lactis subsp. cremoris (strain NZ9000)Imported
Taxonomic identifieri746361 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000007090: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD8KFQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 335204ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000011593.
KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8KFQ1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKETLILLY GGRSAEREVS VLSAESVMRA VNYSRFIVKT YFITKGGEFI
60 70 80 90 100
KTQEFTDRPA EEEKLLTNDL AESYPKISPA AIYEKDAVVF PVLHGPMGED
110 120 130 140 150
GSIQGFLEIL RLAYVGPNIL SASSTMDKLL AKHVFEAVGV PQVPYVAAFA
160 170 180 190 200
DENQVEIAQE VVEKLDFPVF VKPANMGSSV GISKVDDLAD LQPALSEAYK
210 220 230 240 250
YDNRVVIEQG VDAREIECAV LGNNSDVSAT LPGEVVKDVG FYDYNSKYID
260 270 280 290 300
NKIQMDIPAK VSADLAQKIQ EYAKKAYKAV NGAGLSRCDF FVTKDGNVYL
310 320 330 340
NEVNAIPGFT QWSMYPLLWE NMGLSYSDLI EKLVDLAKET FETRENHLL
Length:349
Mass (Da):38,678
Last modified:October 5, 2010 - v1
Checksum:iE5453E652B2CE526
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002094 Genomic DNA. Translation: ADJ59381.1.
RefSeqiWP_011834418.1. NC_017949.1.
YP_006355803.1. NC_017949.1.

Genome annotation databases

EnsemblBacteriaiADJ59381; ADJ59381; LLNZ_01885.
GeneIDi13019002.
KEGGilln:LLNZ_01885.
PATRICi43094110. VBILacLac151604_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002094 Genomic DNA. Translation: ADJ59381.1 .
RefSeqi WP_011834418.1. NC_017949.1.
YP_006355803.1. NC_017949.1.

3D structure databases

ProteinModelPortali D8KFQ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADJ59381 ; ADJ59381 ; LLNZ_01885 .
GeneIDi 13019002.
KEGGi lln:LLNZ_01885.
PATRICi 43094110. VBILacLac151604_0370.

Phylogenomic databases

HOGENOMi HOG000011593.
KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LLAC746361:GLFF-377-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of Lactococcus lactis MG1363 (revised) and NZ9000 and comparative physiological studies."
    Linares D.M., Kok J., Poolman B.
    J. Bacteriol. 192:5806-5812(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NZ9000Imported.

Entry informationi

Entry nameiD8KFQ1_LACLN
AccessioniPrimary (citable) accession number: D8KFQ1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3