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D8KCN3

- D8KCN3_LACLN

UniProt

D8KCN3 - D8KCN3_LACLN

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Protein

Alanine racemase

Gene

alr

Organism
Lactococcus lactis subsp. cremoris (strain NZ9000)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLLAC746361:GLFF-1713-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:LLNZ_08785Imported
OrganismiLactococcus lactis subsp. cremoris (strain NZ9000)Imported
Taxonomic identifieri746361 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000007090: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD8KCN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8KCN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTSPHRNTS AIVDLKAIRN NIEKFKKHIN PNAEIWPAVK ADAYGHGSIE
60 70 80 90 100
VSKAVSDLVG GFCVSNLDEA IELRNHLVTK PILVLSGIVP EDVDIAAALN
110 120 130 140 150
ISLTAPSLEW LKLVVQEEAE LSDLKIHIGV DSGMGRIGIR DVEEANQMIE
160 170 180 190 200
LADKYAINFE GIFTHFATAD MADETKFKNQ QARFNKIMAG LSRQPKFIHS
210 220 230 240 250
TNTAAALWHK EQVQAIERLG ISMYGLNPSG KTLELPFEIE PALSLVSELT
260 270 280 290 300
HIKKIAAGET VGYGATYETS EETWIGTVPI GYADGWTRQM QGFKVLVDGK
310 320 330 340 350
FCEIVGRVCM DQMMIKLDKS YPLGTKVTLI GRDKANEITT TDVADWRGTI
360
NYEVLCLLSD RIKRIYK
Length:367
Mass (Da):40,677
Last modified:October 5, 2010 - v1
Checksum:iB6DE1496315FA814
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002094 Genomic DNA. Translation: ADJ60689.1.
RefSeqiWP_011835506.1. NC_017949.1.
YP_006357111.1. NC_017949.1.

Genome annotation databases

EnsemblBacteriaiADJ60689; ADJ60689; LLNZ_08785.
GeneIDi13020338.
KEGGilln:LLNZ_08785.
PATRICi43096986. VBILacLac151604_1768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002094 Genomic DNA. Translation: ADJ60689.1 .
RefSeqi WP_011835506.1. NC_017949.1.
YP_006357111.1. NC_017949.1.

3D structure databases

ProteinModelPortali D8KCN3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADJ60689 ; ADJ60689 ; LLNZ_08785 .
GeneIDi 13020338.
KEGGi lln:LLNZ_08785.
PATRICi 43096986. VBILacLac151604_1768.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci LLAC746361:GLFF-1713-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of Lactococcus lactis MG1363 (revised) and NZ9000 and comparative physiological studies."
    Linares D.M., Kok J., Poolman B.
    J. Bacteriol. 192:5806-5812(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NZ9000Imported.

Entry informationi

Entry nameiD8KCN3_LACLN
AccessioniPrimary (citable) accession number: D8KCN3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3