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D8KAS8 (D8KAS8_NITWC) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP-Rule MF_00220
Short name=DHOase HAMAP-Rule MF_00220
EC=3.5.2.3 HAMAP-Rule MF_00220
Gene names
Name:pyrC HAMAP-Rule MF_00220
Ordered Locus Names:Nwat_2739 EMBL ADJ29505.1
OrganismNitrosococcus watsoni (strain C-113) [Complete proteome] [HAMAP]
Taxonomic identifier105559 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Nitrosococcus ›

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP-Rule MF_00220

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_00220

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP-Rule MF_00220

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00220

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. HAMAP-Rule MF_00220

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2331Zinc 2 By similarity HAMAP-Rule MF_00220
Metal binding3061Zinc 1 By similarity HAMAP-Rule MF_00220

Sequences

Sequence LengthMass (Da)Tools
D8KAS8 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 7941831A838C0D36

FASTA42946,478
        10         20         30         40         50         60 
MRTLIRGGRL IDPYNGIDGL QDLYLAEGRV IAIGSAPEDF RVEQTIDAQD QIVCPGLIDL 

        70         80         90        100        110        120 
QARLREPGQE QKGTIATETL AAAKGGITTL CCPPDTLAII DTPAVVDLIA HREAQYQRTR 

       130        140        150        160        170        180 
ILPLGALTQG LQGLQLAEMG ILQEAGCVGV SNGLMPITNS QVMRQAMEYA ATLGITLFLY 

       190        200        210        220        230        240 
PRDPWLGIEG CCHEGIVSAR LGLAGIPETA ETVSLARDLL LIEQTGVQAH FCHLSSARAV 

       250        260        270        280        290        300 
RMVRQAQTEG LPISADVTAY HLHLTEHDIG EFDSQCHVIP PLRTLRDRDA LHEGLREGTF 

       310        320        330        340        350        360 
SAICSDHQPH EVDAKLGAFP ITEPGISGLE TLLPLSLRLT QDDILTLPEV IAYLTCQPAQ 

       370        380        390        400        410        420 
VLGIEGGHLA PGQRADICIF DPHCHWIFKP EEMASQGKNT PFGGWEFQGR VTYTLLEGRV 


VFAAAAETL

« Hide

References

[1]"Complete sequence of chromosome of Nitrosococcus watsoni C-113."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Malfatti S.A., Chain P.S.G., Land M., Hauser L., Kyrpides N., Ivanova N., Cambell M.A., Heidelberg J.F., Klotz M.G., Woyke T.
Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C-113 EMBL ADJ29505.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002086 Genomic DNA. Translation: ADJ29505.1.
RefSeqYP_003761826.1. NC_014315.1.

3D structure databases

ProteinModelPortalD8KAS8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ29505; ADJ29505; Nwat_2739.
GeneID9394236.
KEGGnwa:Nwat_2739.
PATRIC42238167. VBINitWat28885_2935.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01465.

Enzyme and pathway databases

BioCycNWAT105559:GHXU-2788-MONOMER.
UniPathwayUPA00070; UER00117.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
InterProIPR004722. DHOase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. pyrC_multi. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD8KAS8_NITWC
AccessionPrimary (citable) accession number: D8KAS8
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 29, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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