Skip Header

Contribute Send feedback
Read comments (?) or add your own

D8JZ18 (D8JZ18_HYPDA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain HAMAP-Rule MF_01209
EC=6.3.5.5 HAMAP-Rule MF_01209
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain HAMAP-Rule MF_01209
Gene names
Name:carA HAMAP-Rule MF_01209
Ordered Locus Names:Hden_1817
OrganismHyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415) [Complete proteome] [HAMAP]
Taxonomic identifier582899 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Hyphomicrobiaceae › Hyphomicrobium ›

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP-Rule MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP-Rule MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP-Rule MF_01209 SAAS SAAS006274

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. HAMAP-Rule MF_01209

Sequence similarities

Belongs to the CarA family. HAMAP-Rule MF_01209

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01209

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain205 – 393189Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01209
Region1 – 201201CPSase By similarity HAMAP-Rule MF_01209

Sites

Active site2821Nucleophile By similarity HAMAP-Rule MF_01209
Active site3661 By similarity HAMAP-Rule MF_01209
Active site3681 By similarity HAMAP-Rule MF_01209

Sequences

Sequence LengthMass (Da)Tools
D8JZ18 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: A61B1CA291242079

FASTA39943,082
        10         20         30         40         50         60 
MTAPEPWTDV PLTARLVFDD GTVIAGRGLG ATGSAVGEVC FNTAITGYQE ILTDPSYAGQ 

        70         80         90        100        110        120 
IITFTFPHIG NVGANSEDTE TSNLASRSGV RGCVLRADIT EPSNYRSAEN LDAWLKTRGI 

       130        140        150        160        170        180 
IAISGIDTRA LTARIREKGM PNAVIAHDPS GNFDIDKLKA EAKAWSGLLG LDLVPDVTSG 

       190        200        210        220        230        240 
QSYSWDEQRW VWNQGFTRNE NPEFHVVAID YGLKRNILRC LASAGCKVTV VPATEKAEDV 

       250        260        270        280        290        300 
LARNPDGVFL SNGPGDPAAT GEYAVPEIKK LVESGKPVFG ICLGHQMLGL ALGGKTRKMH 

       310        320        330        340        350        360 
QGHHGANHPV KDFTTNKVEI VSMNHGFAVD RDSLPKGVVE THVSLFDGSN CGLALEGKPV 

       370        380        390 
FSVQHHPEAS PGPQDSHYLF TRFVNLMREQ KGQAARRER

« Hide

References

[1]"Genome sequences of eight morphologically diverse alphaproteobacteria."
US DOE Joint Genome Institute
Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.
J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002083 Genomic DNA. Translation: ADJ23620.1.
RefSeqYP_003755941.1. NC_014313.1.

3D structure databases

ProteinModelPortalD8JZ18.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ23620; ADJ23620; Hden_1817.
GeneID9387710.
KEGGhdn:Hden_1817.
PATRIC42372271. VBIHypDen91677_1870.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000038087.
KOK01956.
OMARDSHYLF.

Enzyme and pathway databases

BioCycHDEN582899:GIWL-1837-MONOMER.
UniPathwayUPA00068; UER00171.
UPA00070; UER00115.

Family and domain databases

Gene3D3.50.30.20. 1 hit.
HAMAPMF_01209. CPSase_S_chain.
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8JZ18_HYPDA
AccessionPrimary (citable) accession number: D8JZ18
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info