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Protein

Superoxide dismutase [Cu-Zn]

Gene

Hden_1373

Organism
Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciHDEN582899:GIWL-1392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Hden_1373Imported
OrganismiHyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415)Imported
Taxonomic identifieri582899 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium
ProteomesiUP000002033: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 178153 PotentialImportedPRO_5000614346Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD8JX49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiGARYACG.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D8JX49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRRALHLVL GCCFGIALSA SAYAADVSVD INKITPDGVG DKIGTVVISE
60 70 80 90 100
KSGGGLQFKV DITGVTPGEH GFHVHATGDC AAQTKDGKLQ AGLAAGPHYD
110 120 130 140 150
PTSSKSHKGP TGQGHKGDLP FLTATDKGIN VVVSAPHLTL ADVSGRALMI
160 170
HEGGDNYTDH PENGGGKGRI ACGVVPKS
Length:178
Mass (Da):18,129
Last modified:October 5, 2010 - v1
Checksum:i056FEAB63DF0717E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002083 Genomic DNA. Translation: ADJ23185.1.
RefSeqiWP_013215400.1. NC_014313.1.
YP_003755506.1. NC_014313.1.

Genome annotation databases

EnsemblBacteriaiADJ23185; ADJ23185; Hden_1373.
GeneIDi9387265.
KEGGihdn:Hden_1373.
PATRICi42371375. VBIHypDen91677_1424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002083 Genomic DNA. Translation: ADJ23185.1.
RefSeqiWP_013215400.1. NC_014313.1.
YP_003755506.1. NC_014313.1.

3D structure databases

ProteinModelPortaliD8JX49.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADJ23185; ADJ23185; Hden_1373.
GeneIDi9387265.
KEGGihdn:Hden_1373.
PATRICi42371375. VBIHypDen91677_1424.

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiGARYACG.

Enzyme and pathway databases

BioCyciHDEN582899:GIWL-1392-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415Imported.

Entry informationi

Entry nameiD8JX49_HYPDA
AccessioniPrimary (citable) accession number: D8JX49
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.