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D8JU15 (D8JU15_HYPDA) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hydroxyacylglutathione hydrolase HAMAP-Rule MF_01374
EC=3.1.2.6 HAMAP-Rule MF_01374
Alternative name(s):
Glyoxalase II HAMAP-Rule MF_01374
Gene names
Name:gloB HAMAP-Rule MF_01374
Ordered Locus Names:Hden_2767
OrganismHyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415) [Complete proteome] [HAMAP]
Taxonomic identifier582899 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Hyphomicrobiaceae › Hyphomicrobium ›

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP-Rule MF_01374 SAAS SAAS017782

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP-Rule MF_01374 SAAS SAAS017782

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_01374 SAAS SAAS017782

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP-Rule MF_01374

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01374 SAAS SAAS017782

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. HAMAP-Rule MF_01374

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding671Zinc 1 By similarity HAMAP-Rule MF_01374
Metal binding691Zinc 1 By similarity HAMAP-Rule MF_01374
Metal binding711Zinc 2 By similarity HAMAP-Rule MF_01374
Metal binding721Zinc 2 By similarity HAMAP-Rule MF_01374
Metal binding1251Zinc 1 By similarity HAMAP-Rule MF_01374
Metal binding1441Zinc 1 By similarity HAMAP-Rule MF_01374
Metal binding1441Zinc 2 By similarity HAMAP-Rule MF_01374
Metal binding1821Zinc 2 By similarity HAMAP-Rule MF_01374

Sequences

Sequence LengthMass (Da)Tools
D8JU15 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 71DB99861334A6FD

FASTA26628,857
        10         20         30         40         50         60 
MSVEPYQTLG MATFEIVLLP CLADNYCVLL HDPVSGETAA IDAPQAATIK AALDARNWRL 

        70         80         90        100        110        120 
NHLFITHHHT DHTAGIAELK GHYGASVTGP EAEAERIPGL TRGVTEATQL EFAGHPIRVL 

       130        140        150        160        170        180 
ETPGHTLGHV TFHLPDDGLV FTGDTLFSLG CGRIFEGDPQ MMWNSVSKIA ALPGDTRIYC 

       190        200        210        220        230        240 
GHEYTLGNAR FAMNVELENA ALKARVADVE AARTAGEATI PTTIDLEKAT NPFLRPGSRM 

       250        260 
IRARLGLDGA PDWEVFARLR QLKNKA

« Hide

References

[1]"Genome sequences of eight morphologically diverse alphaproteobacteria."
US DOE Joint Genome Institute
Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.
J. Bacteriol. 193:4567-4568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002083 Genomic DNA. Translation: ADJ24563.1.
RefSeqYP_003756884.1. NC_014313.1.

3D structure databases

ProteinModelPortalD8JU15.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ24563; ADJ24563; Hden_2767.
GeneID9388679.
KEGGhdn:Hden_2767.
PATRIC42374313. VBIHypDen91677_2874.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000058041.
KOK01069.
OMAPFMRVHE.

Enzyme and pathway databases

BioCycHDEN582899:GIWL-2806-MONOMER.
UniPathwayUPA00619; UER00676.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
InterProIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFPIRSF005457. Glx. 1 hit.
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD8JU15_HYPDA
AccessionPrimary (citable) accession number: D8JU15
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info