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Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotationSAAS annotation

Catalytic activityi

L-aspartate-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthio-L-aspartate-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.UniRule annotationSAAS annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi70Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi99Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi166Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation1
Metal bindingi170Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation1
Metal bindingi173Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHDEN582899:G1GLW-303-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S12 methylthiotransferase RimOUniRule annotationSAAS annotation (EC:2.8.4.4UniRule annotationSAAS annotation)
Short name:
S12 MTTaseUniRule annotation
Short name:
S12 methylthiotransferaseUniRule annotation
Alternative name(s):
Ribosomal protein S12 (aspartate-C(3))-methylthiotransferaseUniRule annotation
Ribosome maturation factor RimOUniRule annotation
Gene namesi
Name:rimOUniRule annotation
Ordered Locus Names:Hden_0308Imported
OrganismiHyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415)Imported
Taxonomic identifieri582899 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium
Proteomesi
  • UP000002033 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi582899.Hden_0308

Structurei

3D structure databases

ProteinModelPortaliD8JQY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 135MTTase N-terminalInterPro annotationAdd BLAST111
Domaini392 – 458TRAMInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CBM Bacteria
COG0621 LUCA
HOGENOMiHOG000224766
KOiK14441
OMAiCLSERYK
OrthoDBiPOG091H006S

Family and domain databases

Gene3Di3.40.50.121601 hit
3.80.30.201 hit
HAMAPiMF_01865 MTTase_RimO, 1 hit
InterProiView protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR005840 Ribosomal_S12_MeSTrfase_RimO
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom
PANTHERiPTHR43837 PTHR43837, 1 hit
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF00919 UPF0004, 1 hit
SFLDiSFLDF00274 ribosomal_protein_S12_methylth, 1 hit
SFLDG01061 methylthiotransferase, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR00089 TIGR00089, 1 hit
TIGR01125 TIGR01125, 1 hit
PROSITEiView protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

Sequencei

Sequence statusi: Complete.

D8JQY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPSVKVNA KARRAAHGSD TAAAPKVGFV SLGCPKALVD SERIITKLRA
60 70 80 90 100
EGYMIASDYE GADVVVVNTC GFLDSAKKES LDAIGEAMNA NGRVIVTGCF
110 120 130 140 150
GVEENRIRDA HPGVLAVTGP HQYEQVVEAV HDAVPPLHDP FVDLVPPEGL
160 170 180 190 200
RLTPRHYAYL KISEGCNNRC SFCIIPALRG DLASRPSNHV MGEAERLVNA
210 220 230 240 250
GVKELLVISQ DTSAYGLDIK YAESAWKGAP LKARFLDLSR ALGDLGVWVR
260 270 280 290 300
MHYVYPYPHV DDVIPLMADG KILPYLDIPF QHASPAVLKA MRRPAAQEKT
310 320 330 340 350
AERIRRWREV CPDLAIRSTF IVGFPGETEE DFAFLLDWLK EAGINRAGCF
360 370 380 390 400
KYEPVEGAKA NAIDGAVPDE VKEERWHRFM AVQKDVSSAQ LERKLGQTID
410 420 430 440 450
VLIDEVDEDG AIGRSKWDAP EIDGNVFLNG ERDVNAGDIV RAKVVEAGDY
460
DLWAERVSAN G
Length:461
Mass (Da):50,511
Last modified:October 5, 2010 - v1
Checksum:i6808AC1371C32673
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002083 Genomic DNA Translation: ADJ22133.1
RefSeqiWP_013214352.1, NC_014313.1

Genome annotation databases

EnsemblBacteriaiADJ22133; ADJ22133; Hden_0308
KEGGihdn:Hden_0308

Similar proteinsi

Entry informationi

Entry nameiD8JQY1_HYPDA
AccessioniPrimary (citable) accession number: D8JQY1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported