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Protein

Alanine racemase

Gene

AOLE_06280

Organism
Acinetobacter oleivorans (strain JCM 16667 / KCTC 23045 / DR1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (AOLE_18845), Alanine racemase (AOLE_06280)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Active sitei254Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei302Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:AOLE_06280Imported
OrganismiAcinetobacter oleivorans (strain JCM 16667 / KCTC 23045 / DR1)Imported
Taxonomic identifieri436717 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000392 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi436717.AOLE_06280.

Structurei

3D structure databases

ProteinModelPortaliD8JGJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 356Ala_racemase_CInterPro annotationAdd BLAST124

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031446.
KOiK01775.
OMAiWHLANSG.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

D8JGJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQATVYIDR NALQYNLNRV KQLAANSKIV SMVKANGYGH GIKDCLAALN
60 70 80 90 100
ASDAFGVACL QEGLEIRELG FQQSVTLIEG VFSEDEMPIA IEQKFECVIH
110 120 130 140 150
HQQQFEWLIK YKQKYIAQGL KVWVKLNSGM NRLGFKVTEI IEVIKTLKAE
160 170 180 190 200
GFTCVLAMHF ANADVDHPLN EQQKQQFLQV KQACEPVLAS CCNSAAIYKW
210 220 230 240 250
PELHFDYVRP GIMLYGASPF ADKTVHDLDL KPVMTFSAEV IALNHIQTNE
260 270 280 290 300
HVGYGSTFCA KQAMDIAIVS IGYGDGYPRA YIKQNYVAID KQLCAVVGRV
310 320 330 340 350
SMDMLAIDVT GMQVKLGTPV ELWGAHRLVD DVADANGTIG YELLCRLSNR

PTRKSS
Length:356
Mass (Da):39,688
Last modified:October 5, 2010 - v1
Checksum:i485297CDE784976D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002080 Genomic DNA. Translation: ADI90149.1.
RefSeqiWP_013197334.1. NC_014259.1.

Genome annotation databases

EnsemblBacteriaiADI90149; ADI90149; AOLE_06280.
GeneIDi9381682.
KEGGiacd:AOLE_06280.
PATRICi42141562. VBIAciSp20010_1253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002080 Genomic DNA. Translation: ADI90149.1.
RefSeqiWP_013197334.1. NC_014259.1.

3D structure databases

ProteinModelPortaliD8JGJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436717.AOLE_06280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI90149; ADI90149; AOLE_06280.
GeneIDi9381682.
KEGGiacd:AOLE_06280.
PATRICi42141562. VBIAciSp20010_1253.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031446.
KOiK01775.
OMAiWHLANSG.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD8JGJ5_ACISD
AccessioniPrimary (citable) accession number: D8JGJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.