Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uricase

Gene

HacjB3_16061

Organism
Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.By similarity

Catalytic activityi

Urate + O2 + H2O = 5-hydroxyisourate + H2O2.

Pathwayi: urate degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-allantoin from urate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uricase (HacjB3_16061), Uricase (C497_01190)
  2. no protein annotated in this organism
  3. 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (HacjB3_16066)
This subpathway is part of the pathway urate degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-allantoin from urate, the pathway urate degradation and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651SubstrateBy similarity
Active sitei192 – 1921Charge relay system; for urate oxidase activityBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Active sitei241 – 2411Charge relay system; for urate oxidase activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BioCyciHJEO795797:GKCD-3229-MONOMER.
UniPathwayiUPA00394; UER00650.

Names & Taxonomyi

Protein namesi
Recommended name:
Uricase (EC:1.7.3.3)
Alternative name(s):
Urate oxidase
Gene namesi
Ordered Locus Names:HacjB3_16061
Encoded oniPlasmid 10 Publication
OrganismiHalalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)
Taxonomic identifieri795797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalalkalicoccus
Proteomesi
  • UP000000390 Componenti: Plasmid 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306UricasePRO_0000411961Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni240 – 2412Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the uricase family.Curated

Phylogenomic databases

HOGENOMiHOG000015597.
KOiK00365.

Family and domain databases

InterProiIPR002042. Uricase.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.

Sequencei

Sequence statusi: Complete.

D8JBB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYGKEQVAV YRTYANPLEG VRTIPESSFD GRDNILFGLE VRVQFEGEEF
60 70 80 90 100
LPSFSEADNT TVVATDSMKN FVLHQAGEYE GATAEGFLHF VGTEFLETYP
110 120 130 140 150
HVEAVTMSAT EYPFDERPVP GDDGFDPSDL VFRVSDDESA FGEIYLEREG
160 170 180 190 200
DELRFEEQTS GVTEIELVKV KENSFTGYVQ DEYTTLPERE DRALYISLDV
210 220 230 240 250
FWTYSDPEDA LGDEPQRYVP AEQVRDIAQV VFHEVNSNSI QDLIYQIGLR
260 270 280 290 300
VLERYPQLES VNFEANNRTW IEVRDDLDGD AKVLREPPRP TGYQQFSMDR

SDLEEQ
Length:306
Mass (Da):35,081
Last modified:July 27, 2011 - v2
Checksum:i8986D9831931C1B0
GO

Sequence cautioni

The sequence ADJ16570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002063 Genomic DNA. Translation: ADJ16570.1. Different initiation.
RefSeqiWP_008413873.1. NZ_AXZD01000014.1.

Genome annotation databases

EnsemblBacteriaiADJ16570; ADJ16570; HacjB3_16061.
GeneIDi9421015.
KEGGihje:HacjB3_16061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002063 Genomic DNA. Translation: ADJ16570.1. Different initiation.
RefSeqiWP_008413873.1. NZ_AXZD01000014.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADJ16570; ADJ16570; HacjB3_16061.
GeneIDi9421015.
KEGGihje:HacjB3_16061.

Phylogenomic databases

HOGENOMiHOG000015597.
KOiK00365.

Enzyme and pathway databases

UniPathwayiUPA00394; UER00650.
BioCyciHJEO795797:GKCD-3229-MONOMER.

Family and domain databases

InterProiIPR002042. Uricase.
[Graphical view]
PfamiPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFiPIRSF000241. Urate_oxidase. 1 hit.
PRINTSiPR00093. URICASE.
TIGRFAMsiTIGR03383. urate_oxi. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiURIC_HALJB
AccessioniPrimary (citable) accession number: D8JBB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.