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D8IW66 (D8IW66_HERSS) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlB EMBL ADJ61864.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Hsero_0338 EMBL ADJ61864.1
OrganismHerbaspirillum seropedicae (strain SmR1) [Complete proteome] [HAMAP] EMBL ADJ61864.1
Taxonomic identifier757424 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerbaspirillum

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 315207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding139 – 19456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D8IW66 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 45DB9F217E8665B4

FASTA33436,592
        10         20         30         40         50         60 
MISQDQIKAF GRVGVLFGGR SAEREVSMMS GNGVLQALRS KGVDAHPFDP AERSLGELQA 

        70         80         90        100        110        120 
EQFDRVFIAL HGRYGEDGTL QGALEQMGLP YTGPGVMSSS IAMDKVMTKR IWLSHGLPTP 

       130        140        150        160        170        180 
RFLTLDAQAT TREQLRLVPD TLGLPLMLKA PHEGSTIGIA KVNGYSDMQE GFDLCARYDK 

       190        200        210        220        230        240 
VVLAEEFIRG RELTVPVLGT GSAARALPVI EIRAPEGNYD YQNKYFTDDT KYLCPAPLDE 

       250        260        270        280        290        300 
ELTRHLQNLA VQAFNALGCR GWSRVDFMLR EVDGKAEPYL LEINTSPGMT GHSLVPMAAK 

       310        320        330 
AVGMSYEDLC CEILQMAALD MTPSKDWTPQ AGQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002039 Genomic DNA. Translation: ADJ61864.1.
RefSeqYP_003773772.1. NC_014323.1.

3D structure databases

ProteinModelPortalD8IW66.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ61864; ADJ61864; Hsero_0338.
GeneID9400939.
KEGGhse:Hsero_0338.
PATRIC42359345. VBIHerSer153339_0347.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.

Enzyme and pathway databases

BioCycHSER757424:GCTT-338-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8IW66_HERSS
AccessionPrimary (citable) accession number: D8IW66
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)