ID   D8ICP8_BRAP9            Unreviewed;       432 AA.
AC   D8ICP8;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=BP951000_0923 {ECO:0000313|EMBL:ADK30921.1};
OS   Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC   Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC   Brachyspira.
OX   NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK30921.1, ECO:0000313|Proteomes:UP000000332};
RN   [1] {ECO:0000313|EMBL:ADK30921.1, ECO:0000313|Proteomes:UP000000332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX   PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA   Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA   Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT   "The complete genome sequence of the pathogenic intestinal spirochete
RT   Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL   PLoS ONE 5:E11455-E11455(2010).
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DR   EMBL; CP002025; ADK30921.1; -; Genomic_DNA.
DR   RefSeq; WP_013243875.1; NC_014330.1.
DR   AlphaFoldDB; D8ICP8; -.
DR   STRING; 759914.BP951000_0923; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   GeneID; 56439486; -.
DR   KEGG; bpo:BP951000_0923; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_1_0_12; -.
DR   InParanoid; D8ICP8; -.
DR   Proteomes; UP000000332; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000332};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..432
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003115237"
FT   DOMAIN          107..395
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          21..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  46452 MW;  9B9E8095BAAFAB30 CRC64;
     MSKLKLFLIL ASALLISCAN PNDPGNDTTE GGNGGGGTTP DGKPSWYLSD AQQSSVYQPN
     PVIVFDSKQG DIYRIAGIVE TTKGTLVAVS DSRKTSESDV GFSGAANIDV VVKRSTDGGK
     TWGQAVKIPP IAQKKEDSHG DPLIFSCKDG TLVVLCAAGN AWAQQYGTQN DSKIKMSKSI
     DDGQSWSQWT EIQKVIYDNT TVQGKGFIKG FAASGRGYTD PDTGALYAAV LVGNYGHSKK
     GTVVIKSVDN GTTWTVIGVL EDNGNDEPKV VTRIAEGTHT GKLLLSVRPS TADKRKFFLL
     DENQGEASSI STYAEAGTFN DPTIDAEGMR YTLVKDGHAK NRILHVYLDN NSTRKNLSLV
     MSEDEGKTWI NNKVIQPDLA AYSSIIVLGD GTIGILAEEK NLDTASSSGT YDIVFRRFNL
     KAFNGETYTQ TW
//