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Protein

Isocitrate dehydrogenase [NADP]

Gene

idh

Organism
Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGlyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPIL759914:G1GM2-361-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:idhImported
Ordered Locus Names:BP951000_0369Imported
OrganismiBrachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)Imported
Taxonomic identifieri759914 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesBrachyspiralesBrachyspiraceaeBrachyspira
Proteomesi
  • UP000000332 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi759914.BP951000_0369

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 415Iso_dhInterPro annotationAdd BLAST398

Phylogenomic databases

eggNOGiENOG4108HMX Bacteria
COG0538 LUCA
HOGENOMiHOG000021113
KOiK00031
OMAiFQQIQTR

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004439 Isocitrate_DH_NADP_dimer_prok
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR43504 PTHR43504, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00183 prok_nadp_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

D8IB51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIEMKNGK LIVPNKVTIP FIEGDGVGAE ITPASQMVVN AAVKKAYNGE
60 70 80 90 100
KSIEWLEVLA GDKAQKELGT PLPDETINTF KEYLIGIKGP LTTPVGEGMR
110 120 130 140 150
SLNVALRQTL DLYVCLRPVR WFKGTSSPIK EPNKVNMVVF RENTEDIYAG
160 170 180 190 200
IEWKTGTEEA KKFYNFLKNE MGVTKVRFPE TSSFGVKPVS EEGSKRLIRS
210 220 230 240 250
AIEYALLNKL PSVTLVHKGN IMKFTEGGFK KYGYELARKE FAHQTFTMEE
260 270 280 290 300
YAEIKKEFGE DKAKEKLKEA KEQGKLIIKD NICDAFLQNT LLKPEDYSVI
310 320 330 340 350
ATLNLNGDYI SDQLAAMVGG IGIAPGGNIN YKTGHAIFEA THGTAPDIAG
360 370 380 390 400
KNKANPCSLI LSSVMALEYL NMNEAASLII NALEKSFESG YATEDLASFM
410
DNGTVLGTKE FAEKIVSIM
Length:419
Mass (Da):46,201
Last modified:October 5, 2010 - v1
Checksum:i7ECD11E459E267E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002025 Genomic DNA Translation: ADK30374.1
RefSeqiWP_013243329.1, NC_014330.1

Genome annotation databases

EnsemblBacteriaiADK30374; ADK30374; BP951000_0369
KEGGibpo:BP951000_0369

Similar proteinsi

Entry informationi

Entry nameiD8IB51_BRAP9
AccessioniPrimary (citable) accession number: D8IB51
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 25, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health