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Protein

Isocitrate dehydrogenase [NADP]

Gene

idh

Organism
Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPIL759914:GHZ5-368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:idhImported
Ordered Locus Names:BP951000_0369Imported
OrganismiBrachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)Imported
Taxonomic identifieri759914 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesBrachyspiralesBrachyspiraceaeBrachyspira
ProteomesiUP000000332 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi759914.BP951000_0369.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8IB51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIEMKNGK LIVPNKVTIP FIEGDGVGAE ITPASQMVVN AAVKKAYNGE
60 70 80 90 100
KSIEWLEVLA GDKAQKELGT PLPDETINTF KEYLIGIKGP LTTPVGEGMR
110 120 130 140 150
SLNVALRQTL DLYVCLRPVR WFKGTSSPIK EPNKVNMVVF RENTEDIYAG
160 170 180 190 200
IEWKTGTEEA KKFYNFLKNE MGVTKVRFPE TSSFGVKPVS EEGSKRLIRS
210 220 230 240 250
AIEYALLNKL PSVTLVHKGN IMKFTEGGFK KYGYELARKE FAHQTFTMEE
260 270 280 290 300
YAEIKKEFGE DKAKEKLKEA KEQGKLIIKD NICDAFLQNT LLKPEDYSVI
310 320 330 340 350
ATLNLNGDYI SDQLAAMVGG IGIAPGGNIN YKTGHAIFEA THGTAPDIAG
360 370 380 390 400
KNKANPCSLI LSSVMALEYL NMNEAASLII NALEKSFESG YATEDLASFM
410
DNGTVLGTKE FAEKIVSIM
Length:419
Mass (Da):46,201
Last modified:October 5, 2010 - v1
Checksum:i7ECD11E459E267E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002025 Genomic DNA. Translation: ADK30374.1.
RefSeqiWP_013243329.1. NC_014330.1.

Genome annotation databases

EnsemblBacteriaiADK30374; ADK30374; BP951000_0369.
KEGGibpo:BP951000_0369.
PATRICi42195177. VBIBraPil164347_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002025 Genomic DNA. Translation: ADK30374.1.
RefSeqiWP_013243329.1. NC_014330.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi759914.BP951000_0369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK30374; ADK30374; BP951000_0369.
KEGGibpo:BP951000_0369.
PATRICi42195177. VBIBraPil164347_0363.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.

Enzyme and pathway databases

BioCyciBPIL759914:GHZ5-368-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the pathogenic intestinal spirochete Brachyspira pilosicoli and comparison with other Brachyspira genomes."
    Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B., Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
    PLoS ONE 5:E11455-E11455(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1826 / 95/1000Imported.

Entry informationi

Entry nameiD8IB51_BRAP9
AccessioniPrimary (citable) accession number: D8IB51
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 22, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.