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D8IB51

- D8IB51_BRAP9

UniProt

D8IB51 - D8IB51_BRAP9

Protein

Isocitrate dehydrogenase [NADP]

Gene

idh

Organism
Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBPIL759914:GHZ5-368-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:idhImported
    Ordered Locus Names:BP951000_0369Imported
    OrganismiBrachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)Imported
    Taxonomic identifieri759914 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
    ProteomesiUP000000332: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D8IB51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKIEMKNGK LIVPNKVTIP FIEGDGVGAE ITPASQMVVN AAVKKAYNGE    50
    KSIEWLEVLA GDKAQKELGT PLPDETINTF KEYLIGIKGP LTTPVGEGMR 100
    SLNVALRQTL DLYVCLRPVR WFKGTSSPIK EPNKVNMVVF RENTEDIYAG 150
    IEWKTGTEEA KKFYNFLKNE MGVTKVRFPE TSSFGVKPVS EEGSKRLIRS 200
    AIEYALLNKL PSVTLVHKGN IMKFTEGGFK KYGYELARKE FAHQTFTMEE 250
    YAEIKKEFGE DKAKEKLKEA KEQGKLIIKD NICDAFLQNT LLKPEDYSVI 300
    ATLNLNGDYI SDQLAAMVGG IGIAPGGNIN YKTGHAIFEA THGTAPDIAG 350
    KNKANPCSLI LSSVMALEYL NMNEAASLII NALEKSFESG YATEDLASFM 400
    DNGTVLGTKE FAEKIVSIM 419
    Length:419
    Mass (Da):46,201
    Last modified:October 5, 2010 - v1
    Checksum:i7ECD11E459E267E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002025 Genomic DNA. Translation: ADK30374.1.
    RefSeqiYP_003784875.1. NC_014330.1.

    Genome annotation databases

    EnsemblBacteriaiADK30374; ADK30374; BP951000_0369.
    GeneIDi9450488.
    KEGGibpo:BP951000_0369.
    PATRICi42195177. VBIBraPil164347_0363.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002025 Genomic DNA. Translation: ADK30374.1 .
    RefSeqi YP_003784875.1. NC_014330.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADK30374 ; ADK30374 ; BP951000_0369 .
    GeneIDi 9450488.
    KEGGi bpo:BP951000_0369.
    PATRICi 42195177. VBIBraPil164347_0363.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci BPIL759914:GHZ5-368-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the pathogenic intestinal spirochete Brachyspira pilosicoli and comparison with other Brachyspira genomes."
      Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B., Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
      PLoS ONE 5:E11455-E11455(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1826 / 95/1000Imported.

    Entry informationi

    Entry nameiD8IB51_BRAP9
    AccessioniPrimary (citable) accession number: D8IB51
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3