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D8IB51

- D8IB51_BRAP9

UniProt

D8IB51 - D8IB51_BRAP9

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Protein
Isocitrate dehydrogenase [NADP]
Gene
idh, BP951000_0369
Organism
Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPIL759914:GHZ5-368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:idhImported
Ordered Locus Names:BP951000_0369Imported
OrganismiBrachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)Imported
Taxonomic identifieri759914 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira
ProteomesiUP000000332: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8IB51-1 [UniParc]FASTAAdd to Basket

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MSKIEMKNGK LIVPNKVTIP FIEGDGVGAE ITPASQMVVN AAVKKAYNGE    50
KSIEWLEVLA GDKAQKELGT PLPDETINTF KEYLIGIKGP LTTPVGEGMR 100
SLNVALRQTL DLYVCLRPVR WFKGTSSPIK EPNKVNMVVF RENTEDIYAG 150
IEWKTGTEEA KKFYNFLKNE MGVTKVRFPE TSSFGVKPVS EEGSKRLIRS 200
AIEYALLNKL PSVTLVHKGN IMKFTEGGFK KYGYELARKE FAHQTFTMEE 250
YAEIKKEFGE DKAKEKLKEA KEQGKLIIKD NICDAFLQNT LLKPEDYSVI 300
ATLNLNGDYI SDQLAAMVGG IGIAPGGNIN YKTGHAIFEA THGTAPDIAG 350
KNKANPCSLI LSSVMALEYL NMNEAASLII NALEKSFESG YATEDLASFM 400
DNGTVLGTKE FAEKIVSIM 419
Length:419
Mass (Da):46,201
Last modified:October 5, 2010 - v1
Checksum:i7ECD11E459E267E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002025 Genomic DNA. Translation: ADK30374.1.
RefSeqiYP_003784875.1. NC_014330.1.

Genome annotation databases

EnsemblBacteriaiADK30374; ADK30374; BP951000_0369.
GeneIDi9450488.
KEGGibpo:BP951000_0369.
PATRICi42195177. VBIBraPil164347_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002025 Genomic DNA. Translation: ADK30374.1 .
RefSeqi YP_003784875.1. NC_014330.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADK30374 ; ADK30374 ; BP951000_0369 .
GeneIDi 9450488.
KEGGi bpo:BP951000_0369.
PATRICi 42195177. VBIBraPil164347_0363.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.

Enzyme and pathway databases

BioCyci BPIL759914:GHZ5-368-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the pathogenic intestinal spirochete Brachyspira pilosicoli and comparison with other Brachyspira genomes."
    Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B., Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.
    PLoS ONE 5:E11455-E11455(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1826 / 95/1000.

Entry informationi

Entry nameiD8IB51_BRAP9
AccessioniPrimary (citable) accession number: D8IB51
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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