ID   D8IA56_BRAP9            Unreviewed;       455 AA.
AC   D8IA56;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   Name=ywdH {ECO:0000313|EMBL:ADK32186.1};
GN   OrderedLocusNames=BP951000_2213 {ECO:0000313|EMBL:ADK32186.1};
OS   Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC   Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC   Brachyspira.
OX   NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK32186.1, ECO:0000313|Proteomes:UP000000332};
RN   [1] {ECO:0000313|EMBL:ADK32186.1, ECO:0000313|Proteomes:UP000000332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX   PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA   Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA   Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT   "The complete genome sequence of the pathogenic intestinal spirochete
RT   Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL   PLoS ONE 5:E11455-E11455(2010).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC       ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP002025; ADK32186.1; -; Genomic_DNA.
DR   RefSeq; WP_013245135.1; NC_014330.1.
DR   AlphaFoldDB; D8IA56; -.
DR   STRING; 759914.BP951000_2213; -.
DR   GeneID; 56440761; -.
DR   KEGG; bpo:BP951000_2213; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_3_1_12; -.
DR   InParanoid; D8IA56; -.
DR   Proteomes; UP000000332; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR036492};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000332}.
FT   DOMAIN          11..423
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        208
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        243
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ   SEQUENCE   455 AA;  52199 MW;  832F4D6157FCD215 CRC64;
     MYIEELRNKQ REFFKSGATL EYSFRIEQLK KLKAMIIKNE ANFIDALNKD MAKLEFEAIG
     TELFIIIDEI NLFIKKLKTW MKDKKVKRNF LTIDSKTIIM NKPYGVSLII SPWNYPLQLT
     FLPLIGSIAG GNTSIILPSQ LTTNVYDAIY SSVKETFDEE YIAVVDKSFP AEETTKIEYD
     KIFFTGSPRV GKIIMNNASN FLTSLTLELG GKSPVIVDDN IKNINKALKR IIWGKFINSG
     QTCVSPDYLL VNKNIKDKFL EAFKAEIKLF EDERKLNRII NKSHYERLKS YLNDGKILYG
     GEYDDESLSL AITLLEPNSL ENNVMKDEIF GSIFPIVYYS TKEEARDIID KVCSHPLAMY
     VFSDDNNFVE YFLNNISFGG ASVNDTISHI LNNNAPFGGV STSGIGEYHG YYSFECFTNK
     TTVLKKNYNF ELNTKYPPYS KNIKALKFLF ELFKK
//