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D8HWA8 (D8HWA8_AMYMU) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339

Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfk EMBL ADJ44256.1
Synonyms:pfkA HAMAP-Rule MF_00339
Ordered Locus Names:AMED_2460 EMBL ADJ44256.1
OrganismAmycolatopsis mediterranei (strain U-32) [Complete proteome] [HAMAP] EMBL ADJ44256.1
Taxonomic identifier749927 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding20 – 245ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding154 – 1585ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding171 – 18717ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1271Proton acceptor By similarity HAMAP-Rule MF_00339
Binding site1621Substrate By similarity HAMAP-Rule MF_00339
Binding site2651Substrate By similarity HAMAP-Rule MF_00339
Binding site2711Substrate By similarity HAMAP-Rule MF_00339
Binding site2741Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
D8HWA8 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 2B5C28E7BBD57065

FASTA34136,272
        10         20         30         40         50         60 
MRVGVLTGGG DCPGLNAVIR AVVRKGIEVH GWDFVGFRNG WNGPLTGDSR PLGLNDVEDI 

        70         80         90        100        110        120 
LTRGGTILRS SRTNPYKVEG GVDKIKQVLA DQGVDALIAI GGEDTLGVAK RLTDDGIGVV 

       130        140        150        160        170        180 
GVPKTIDNDL GATDYTFGFD TAVSIATEAI DRLHTTAESH HRALVVEVMG RHAGWIALHS 

       190        200        210        220        230        240 
GLAGGASVIL VPERHFNVDQ VVSWVERRFE KEFAPIIVVA EGALPEGGEE KLLTGEKDAF 

       250        260        270        280        290        300 
GHVRLGGIGT WLADEIAHRT GKESRAVVLG HVQRGGTPTA YDRVLATRFG LNAVDAVADG 

       310        320        330        340 
DFGVMVALKG TDIVRVKLSE ATAELKTVPV ERYQEAEVFF G 

« Hide

References

[1]"Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y. expand/collapse author list , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: U-32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002000 Genomic DNA. Translation: ADJ44256.1.
RefSeqYP_003764658.1. NC_014318.1.

3D structure databases

ProteinModelPortalD8HWA8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ44256; ADJ44256; AMED_2460.
GeneID9436666.
KEGGamd:AMED_2460.
PATRIC42151979. VBIAmyMed151214_2537.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000248869.
KOK00850.
OMAIPEIPYK.

Enzyme and pathway databases

BioCycAMED749927:GCZN-2457-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012829. PFK.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02483. PFK_mixed. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8HWA8_AMYMU
AccessionPrimary (citable) accession number: D8HWA8
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)