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D8HU19 (D8HU19_AMYMU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase HAMAP-Rule MF_00150
Short name=AGPR HAMAP-Rule MF_00150
EC=1.2.1.38 HAMAP-Rule MF_00150
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase HAMAP-Rule MF_00150
Gene names
Name:argC HAMAP-Rule MF_00150 EMBL ADJ47785.1
Ordered Locus Names:AMED_6044
OrganismAmycolatopsis mediterranei (strain U-32) [Complete proteome] [HAMAP] EMBL ADJ47785.1
Taxonomic identifier749927 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Amycolatopsis ›

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP-Rule MF_00150 SAAS SAAS023013

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP-Rule MF_00150 SAAS SAAS023013

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00150 SAAS SAAS023013.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. HAMAP-Rule MF_00150

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1461 By similarity HAMAP-Rule MF_00150

Sequences

Sequence LengthMass (Da)Tools
D8HU19 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 468717255ED492A1

FASTA34234,530
        10         20         30         40         50         60 
MTVNIAVAGA SGYAGGELLR LLLTHPGVEI GALTAASSAG TKLGVHQPHL VPLADRVLAE 

        70         80         90        100        110        120 
TTPETLAGHD VVFLALPHGH SAAIAVQLGP DVLVVDLGAD HRLADAGDWQ RWYGGDHAGQ 

       130        140        150        160        170        180 
WPYGLPELPG ARERLAGTKR IAVPGCFPTG GSLALAPAFA AGLIEPDVTI VAVTGTSGAG 

       190        200        210        220        230        240 
KSLKPNLLGS EVMGSASAYG VGGAHRHTPE FVQNLSAVAG EKVTVSFTPV LAPMPRGILT 

       250        260        270        280        290        300 
TASASLKNGV DEAAARAAYE KAYDAEPFVQ LLPAGAWPAT ASTLGSNNTQ LQVTVDTDAK 

       310        320        330        340 
RLVVVAAIDN LTKGTAGGAV QSMNLALGLP ETTGLPTVGV AP

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References

[1]"Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y. expand/collapse author list , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: U-32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002000 Genomic DNA. Translation: ADJ47785.1.
RefSeqYP_003768187.1. NC_014318.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ47785; ADJ47785; AMED_6044.
GeneID9440207.
KEGGamd:AMED_6044.
PATRIC42159493. VBIAmyMed151214_6285.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000254904.
KOK00145.

Enzyme and pathway databases

UniPathwayUPA00068; UER00108.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00150. ArgC_type1.
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. argC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8HU19_AMYMU
AccessionPrimary (citable) accession number: D8HU19
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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