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D8HQR7 (D8HQR7_AMYMU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine recombinase XerC HAMAP-Rule MF_01808
Gene names
Name:xerC HAMAP-Rule MF_01808 EMBL ADJ43778.1
Ordered Locus Names:AMED_1970
OrganismAmycolatopsis mediterranei (strain U-32) [Complete proteome] [HAMAP] EMBL ADJ43778.1
Taxonomic identifier749927 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Amycolatopsis ›

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity. HAMAP-Rule MF_01808

Subunit structure

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD By similarity. HAMAP-Rule MF_01808

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01808 SAAS SAAS010998.

Sequence similarities

Belongs to the 'phage' integrase family. XerC subfamily. HAMAP-Rule MF_01808

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1731 By similarity HAMAP-Rule MF_01808
Active site1971 By similarity HAMAP-Rule MF_01808
Active site2721 By similarity HAMAP-Rule MF_01808
Active site2751 By similarity HAMAP-Rule MF_01808
Active site2981 By similarity HAMAP-Rule MF_01808
Active site3071O-(3'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01808

Sequences

Sequence LengthMass (Da)Tools
D8HQR7 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 21EA5AC38F243002

FASTA32634,453
        10         20         30         40         50         60 
MPPPRSGRAR RPDLRALRAA LPEPVRAVVT AYERHLGLER GLSAHTVRAY VGDAVSLLGF 

        70         80         90        100        110        120 
VVDGGSEVAE LDLARLRAWL AAQQSGGASR TTLARRAASA RTFTAWAHRT GVLATDPGGR 

       130        140        150        160        170        180 
LAAPRAHRTL PGVLRAGQAG EVMQASAAGA AQRDPVALRD RAIVELLYAT GIRVSELCGL 

       190        200        210        220        230        240 
DVGEADFSRR VVTVLGKGGK ERVVPFGVPA AEALADWIDE GRPKIITESG GESAEAALFL 

       250        260        270        280        290        300 
GVRGKRVDPR AVRRVVHDAV TAVPGALDMG PHGLRHSAAT HLLEGGADLR SVQELLGHAT 

       310        320 
LATTQLYTHV TVDRLKAIHD RAHPRA

« Hide

References

[1]"Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y. expand/collapse author list , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: U-32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002000 Genomic DNA. Translation: ADJ43778.1.
RefSeqYP_003764180.1. NC_014318.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADJ43778; ADJ43778; AMED_1970.
GeneID9436184.
KEGGamd:AMED_1970.
PATRIC42150959. VBIAmyMed151214_2031.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000045294.
KOK03733.

Family and domain databases

Gene3D1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPMF_01808. Recomb_XerC.
InterProIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR010998. Integrase_Lambda-type_N.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamPF02899. Phage_integr_N. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMSSF56349. DNA_brk_join_enz. 1 hit.
SSF47823. L_intgrse_like_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD8HQR7_AMYMU
AccessionPrimary (citable) accession number: D8HQR7
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info