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D8HLT9

- D8HLT9_AMYMU

UniProt

D8HLT9 - D8HLT9_AMYMU

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Protein

DNA ligase

Gene

lig

Organism
Amycolatopsis mediterranei (strain U-32)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMED749927:GCZN-7994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:ligImported
Ordered Locus Names:AMED_8064Imported
OrganismiAmycolatopsis mediterranei (strain U-32)Imported
Taxonomic identifieri749927 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis
ProteomesiUP000000328: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8HLT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLSELVRAS AELAATRSRK AKIALLAELL RAAEIAELPT VIAYLTGQTA
60 70 80 90 100
QDRLGAGWRT LAALGAGAAA GPVASVLEVD AALTAAAGVA AGTGSSTRRQ
110 120 130 140 150
EVLRALFERL TKDEQQFLFR LVTGELRQGA LEGVMVDAIA AAAEVPAEDV
160 170 180 190 200
RRAFMLSGKL GVTGVAAMTG GQAALAEFRL TLGTPIKPML ASPAESLDEA
210 220 230 240 250
VAEHAEAIVE YKMDGARIQV HRQGDEVHVW TRTLREITGS VQELVDLVRA
260 270 280 290 300
LPCESVVLDG ETLALTDAGR PRPFQDTMSR FGSTREEQVK ALLLRPYFFD
310 320 330 340 350
CLHLDGVDLL DAPLSERNAA LRKVAGAHVI PGEVGTAGAA AVLEAAMEAG
360 370 380 390 400
HEGVMVKDLA APYAAGRRGR AWLKVKPVHT IDLVVLAAEW GHGRRTGTLS
410 420 430 440 450
NLHLGARDPD GGPPIMVGKT FKGMTDELLA WQTRTFQEIE THRDEWTVYV
460 470 480 490 500
RPEVVVEIEL DSAQVSTRYP GGLALRFARV VRYRPDKDPA DADTIDTVRG
510
LLHGDRSEGS
Length:510
Mass (Da):54,598
Last modified:October 5, 2010 - v1
Checksum:i1A349D55022D5068
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002000 Genomic DNA. Translation: ADJ49767.1.
RefSeqiYP_003770169.1. NC_014318.1.

Genome annotation databases

EnsemblBacteriaiADJ49767; ADJ49767; AMED_8064.
GeneIDi9442203.
KEGGiamd:AMED_8064.
PATRICi42163709. VBIAmyMed151214_8380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002000 Genomic DNA. Translation: ADJ49767.1 .
RefSeqi YP_003770169.1. NC_014318.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADJ49767 ; ADJ49767 ; AMED_8064 .
GeneIDi 9442203.
KEGGi amd:AMED_8064.
PATRICi 42163709. VBIAmyMed151214_8380.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci AMED749927:GCZN-7994-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
    Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y.
    , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
    Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: U-32Imported.

Entry informationi

Entry nameiD8HLT9_AMYMU
AccessioniPrimary (citable) accession number: D8HLT9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3