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D8HLT9

- D8HLT9_AMYMU

UniProt

D8HLT9 - D8HLT9_AMYMU

Protein

DNA ligase

Gene

lig

Organism
Amycolatopsis mediterranei (strain U-32)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAMED749927:GCZN-7994-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:ligImported
    Ordered Locus Names:AMED_8064Imported
    OrganismiAmycolatopsis mediterranei (strain U-32)Imported
    Taxonomic identifieri749927 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis
    ProteomesiUP000000328: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D8HLT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLSELVRAS AELAATRSRK AKIALLAELL RAAEIAELPT VIAYLTGQTA    50
    QDRLGAGWRT LAALGAGAAA GPVASVLEVD AALTAAAGVA AGTGSSTRRQ 100
    EVLRALFERL TKDEQQFLFR LVTGELRQGA LEGVMVDAIA AAAEVPAEDV 150
    RRAFMLSGKL GVTGVAAMTG GQAALAEFRL TLGTPIKPML ASPAESLDEA 200
    VAEHAEAIVE YKMDGARIQV HRQGDEVHVW TRTLREITGS VQELVDLVRA 250
    LPCESVVLDG ETLALTDAGR PRPFQDTMSR FGSTREEQVK ALLLRPYFFD 300
    CLHLDGVDLL DAPLSERNAA LRKVAGAHVI PGEVGTAGAA AVLEAAMEAG 350
    HEGVMVKDLA APYAAGRRGR AWLKVKPVHT IDLVVLAAEW GHGRRTGTLS 400
    NLHLGARDPD GGPPIMVGKT FKGMTDELLA WQTRTFQEIE THRDEWTVYV 450
    RPEVVVEIEL DSAQVSTRYP GGLALRFARV VRYRPDKDPA DADTIDTVRG 500
    LLHGDRSEGS 510
    Length:510
    Mass (Da):54,598
    Last modified:October 5, 2010 - v1
    Checksum:i1A349D55022D5068
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002000 Genomic DNA. Translation: ADJ49767.1.
    RefSeqiYP_003770169.1. NC_014318.1.

    Genome annotation databases

    EnsemblBacteriaiADJ49767; ADJ49767; AMED_8064.
    GeneIDi9442203.
    KEGGiamd:AMED_8064.
    PATRICi42163709. VBIAmyMed151214_8380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002000 Genomic DNA. Translation: ADJ49767.1 .
    RefSeqi YP_003770169.1. NC_014318.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADJ49767 ; ADJ49767 ; AMED_8064 .
    GeneIDi 9442203.
    KEGGi amd:AMED_8064.
    PATRICi 42163709. VBIAmyMed151214_8380.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci AMED749927:GCZN-7994-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
      Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y.
      , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
      Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U-32Imported.

    Entry informationi

    Entry nameiD8HLT9_AMYMU
    AccessioniPrimary (citable) accession number: D8HLT9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3