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D8HKD3

- D8HKD3_AMYMU

UniProt

D8HKD3 - D8HKD3_AMYMU

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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Amycolatopsis mediterranei (strain U-32)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciAMED749927:GCZN-8795-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:AMED_8869Imported
OrganismiAmycolatopsis mediterranei (strain U-32)Imported
Taxonomic identifieri749927 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis
ProteomesiUP000000328: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD8HKD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiPTFQINF.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

D8HKD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLHQGKAGR PDRTAGTNPL YAGANPALAA GFVMPHDKLR EDSLPPDTAL
60 70 80 90 100
QLVRDELMLD GNARLNLATF VTTWMEPQAR ELMAECVDKN MIDKDEYPQT
110 120 130 140 150
AELERRCVNI LADLWHAPDP GDVMGCSTTG SSEACMLAGM ALKRRWSKLG
160 170 180 190 200
RTGKPNLVMG ANVQVCWEKF CEYWEVEPRL VPMDGDRYHL TADEAVARCD
210 220 230 240 250
ENTIGVVAIL GSTFDGSYEP VAEIAAALDS LEERTGWDIP VHVDGASGAM
260 270 280 290 300
IAPFLDPHLE WDFRLPRVAS INTSGHKYGL VYPGVGWVLW RDKAALPSEL
310 320 330 340 350
VFNVNYLGGD MPTFALNFSR PGAEVAAQYY TFVRLGREGF RAVQQASRDV
360 370 380 390 400
ALHLSSGIAS LGPFSLLTRG DQLPVFAFTT RPDVGFDVFD VSRRLRERGW
410 420 430 440 450
LVPAYTFPEN RTDLAVLRIV VRNGFTHDLA DLLLADLRRV LPELEQFGGR
460
PKDPAKATAF HH
Length:462
Mass (Da):51,110
Last modified:October 5, 2010 - v1
Checksum:iD2D44AF965447041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002000 Genomic DNA. Translation: ADJ50560.1.
RefSeqiWP_013230584.1. NC_014318.1.
YP_003770962.1. NC_014318.1.

Genome annotation databases

EnsemblBacteriaiADJ50560; ADJ50560; AMED_8869.
GeneIDi9443004.
KEGGiamd:AMED_8869.
PATRICi42165377. VBIAmyMed151214_9209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002000 Genomic DNA. Translation: ADJ50560.1 .
RefSeqi WP_013230584.1. NC_014318.1.
YP_003770962.1. NC_014318.1.

3D structure databases

ProteinModelPortali D8HKD3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADJ50560 ; ADJ50560 ; AMED_8869 .
GeneIDi 9443004.
KEGGi amd:AMED_8869.
PATRICi 42165377. VBIAmyMed151214_9209.

Phylogenomic databases

HOGENOMi HOG000070228.
KOi K01580.
OMAi PTFQINF.

Enzyme and pathway databases

BioCyci AMED749927:GCZN-8795-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
    Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y.
    , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
    Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: U-32Imported.

Entry informationi

Entry nameiD8HKD3_AMYMU
AccessioniPrimary (citable) accession number: D8HKD3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3