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D8HKD3

- D8HKD3_AMYMU

UniProt

D8HKD3 - D8HKD3_AMYMU

Protein

Glutamate decarboxylase

Gene

gadB

Organism
Amycolatopsis mediterranei (strain U-32)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciAMED749927:GCZN-8795-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadBImported
    Ordered Locus Names:AMED_8869Imported
    OrganismiAmycolatopsis mediterranei (strain U-32)Imported
    Taxonomic identifieri749927 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeAmycolatopsis
    ProteomesiUP000000328: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD8HKD3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiPTFQINF.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D8HKD3-1 [UniParc]FASTAAdd to Basket

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    MVLHQGKAGR PDRTAGTNPL YAGANPALAA GFVMPHDKLR EDSLPPDTAL    50
    QLVRDELMLD GNARLNLATF VTTWMEPQAR ELMAECVDKN MIDKDEYPQT 100
    AELERRCVNI LADLWHAPDP GDVMGCSTTG SSEACMLAGM ALKRRWSKLG 150
    RTGKPNLVMG ANVQVCWEKF CEYWEVEPRL VPMDGDRYHL TADEAVARCD 200
    ENTIGVVAIL GSTFDGSYEP VAEIAAALDS LEERTGWDIP VHVDGASGAM 250
    IAPFLDPHLE WDFRLPRVAS INTSGHKYGL VYPGVGWVLW RDKAALPSEL 300
    VFNVNYLGGD MPTFALNFSR PGAEVAAQYY TFVRLGREGF RAVQQASRDV 350
    ALHLSSGIAS LGPFSLLTRG DQLPVFAFTT RPDVGFDVFD VSRRLRERGW 400
    LVPAYTFPEN RTDLAVLRIV VRNGFTHDLA DLLLADLRRV LPELEQFGGR 450
    PKDPAKATAF HH 462
    Length:462
    Mass (Da):51,110
    Last modified:October 5, 2010 - v1
    Checksum:iD2D44AF965447041
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002000 Genomic DNA. Translation: ADJ50560.1.
    RefSeqiYP_003770962.1. NC_014318.1.

    Genome annotation databases

    EnsemblBacteriaiADJ50560; ADJ50560; AMED_8869.
    GeneIDi9443004.
    KEGGiamd:AMED_8869.
    PATRICi42165377. VBIAmyMed151214_9209.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002000 Genomic DNA. Translation: ADJ50560.1 .
    RefSeqi YP_003770962.1. NC_014318.1.

    3D structure databases

    ProteinModelPortali D8HKD3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADJ50560 ; ADJ50560 ; AMED_8869 .
    GeneIDi 9443004.
    KEGGi amd:AMED_8869.
    PATRICi 42165377. VBIAmyMed151214_9209.

    Phylogenomic databases

    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi PTFQINF.

    Enzyme and pathway databases

    BioCyci AMED749927:GCZN-8795-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism."
      Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y.
      , Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S., Ding X., Zhao G.P.
      Cell Res. 20:1096-1108(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U-32Imported.

    Entry informationi

    Entry nameiD8HKD3_AMYMU
    AccessioniPrimary (citable) accession number: D8HKD3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3