D8HHS1 (D8HHS1_STAAF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex EMBL ADI97552.1

Gene names

Ordered Locus Names:

SAOV_1039 EMBL ADI97552.1

Organism

Staphylococcus aureus subsp. aureus (strain ED133) [Complete proteome] [HAMAP]

Taxonomic identifier

685039 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423 Contains 1 lipoyl-binding domain. RuleBase RU000447

Ontologies

Keywords
Domain	Lipoyl SAAS SAAS003016 RuleBase RU000447
Ligand	Pyruvate EMBL ADI97552.1
Molecular function	Acyltransferase RuleBase RU003765 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D8HHS1 [UniParc]. Last modified October 5, 2010. Version 1. Checksum: D950074B875ACDA8	FASTA	430	46,395
	10 20 30 40 50 60 MAFEFRLPDI GEGIHEGEIV KWFVKAGDTI EEDDVLAEVQ NDKSVVEIPS PVSGTVEEVM 70 80 90 100 110 120 VEEGTVAVVG DVIVKIDAPD AEDMQFKGHD DDSSSKEEPA KEEAPAEQAP VATQTEEVDE 130 140 150 160 170 180 NRTVKAMPSV RKYAREKGVN IKAVSGSGKN GRITKEDVDA YLNGGAPTAS NESAASATNE 190 200 210 220 230 240 EVAETPAAPA AVSLEGDFPE TTEKIPAMRR AIAKAMVNSK HTAPHVTLMD EIDVQALWDH 250 260 270 280 290 300 RKKFKEIAAE QGTKLTFLPY VVKALVSALK KYPALNTSFN EEAGEIVHKH YWNIGIAADT 310 320 330 340 350 360 DRGLLVPVVK HADRKSIFQI SDEINELAVK ARDGKLTADE MKGATCTISN IGSAGGQWFT 370 380 390 400 410 420 PVINHPEVAI LGIGRIAQKP IVKDGEIVAA PVLALSLSFD HRQIDGATGQ NAMNHIKRLL 430 NNPELLLMEG

References

[1]

"Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation." Guinane C.M., Ben Zakour N.L., Tormo-Mas M.A., Weinert L.A., Lowder B.V., Cartwright R.A., Smyth D.S., Smyth C.J., Lindsay J.A., Gould K.A., Witney A., Hinds J., Bollback J.P., Rambaut A., Penades J.R., Fitzgerald J.R. Genome Biol. Evol. 2:454-466(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ED133 EMBL ADI97552.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001996 Genomic DNA. Translation: ADI97552.1.
RefSeq	YP_005736534.1. NC_017337.1.
3D structure databases
ProteinModelPortal	D8HHS1.
SMR	D8HHS1. Positions 2-79, 121-165, 187-428.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADI97552; ADI97552; SAOV_1039.
GeneID	12324406.
KEGG	sue:SAOV_1039.
PATRIC	43197711. VBIStaAur142340_1076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000281564.
KO	K00627.
OMA	GEAFVTP.
Family and domain databases
Gene3D	3.30.559.10. 1 hit. 4.10.320.10. 1 hit.
InterPro	IPR003016. 2-oxoA_DH_lipoyl-BS. IPR001078. 2-oxoacid_DH_actylTfrase. IPR000089. Biotin_lipoyl. IPR023213. CAT-like_dom. IPR004167. E3-bd. IPR011053. Single_hybrid_motif. [Graphical view]
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00364. Biotin_lipoyl. 1 hit. PF02817. E3_binding. 1 hit. [Graphical view]
SUPFAM	SSF47005. E3_bd. 1 hit. SSF51230. Hybrid_motif. 1 hit.
PROSITE	PS50968. BIOTINYL_LIPOYL. 1 hit. PS00189. LIPOYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D8HHS1_STAAF

Accession

Primary (citable) accession number: D8HHS1

Entry history

Integrated into UniProtKB/TrEMBL:	October 5, 2010
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)