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D8HC02

- D8HC02_STAAF

UniProt

D8HC02 - D8HC02_STAAF

Protein

Isocitrate dehydrogenase [NADP]

Gene

citC

Organism
Staphylococcus aureus subsp. aureus (strain ED133)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSAUR685039:GLKK-1678-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:citCImported
    Ordered Locus Names:SAOV_1682Imported
    OrganismiStaphylococcus aureus subsp. aureus (strain ED133)Imported
    Taxonomic identifieri685039 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000388: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiAITIFRE.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D8HC02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN    50
    GEKRIEWKEV LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG 100
    IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPQDVDMV IFRENTEDIY 150
    AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV 200
    RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL TEFGDQVFTW 250
    QQYDEIVEKE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD 300
    VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY 350
    AGLNKVNPSS VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR 400
    LMDGAEEVST SAFADELIKN LK 422
    Length:422
    Mass (Da):46,451
    Last modified:October 5, 2010 - v1
    Checksum:i65BD978D470B6BC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001996 Genomic DNA. Translation: ADI98186.1.
    RefSeqiYP_005737168.1. NC_017337.1.

    Genome annotation databases

    EnsemblBacteriaiADI98186; ADI98186; SAOV_1682.
    GeneIDi12323542.
    KEGGisue:SAOV_1682.
    PATRICi43199074. VBIStaAur142340_1756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001996 Genomic DNA. Translation: ADI98186.1 .
    RefSeqi YP_005737168.1. NC_017337.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI98186 ; ADI98186 ; SAOV_1682 .
    GeneIDi 12323542.
    KEGGi sue:SAOV_1682.
    PATRICi 43199074. VBIStaAur142340_1756.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi AITIFRE.

    Enzyme and pathway databases

    BioCyci SAUR685039:GLKK-1678-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation."
      Guinane C.M., Ben Zakour N.L., Tormo-Mas M.A., Weinert L.A., Lowder B.V., Cartwright R.A., Smyth D.S., Smyth C.J., Lindsay J.A., Gould K.A., Witney A., Hinds J., Bollback J.P., Rambaut A., Penades J.R., Fitzgerald J.R.
      Genome Biol. Evol. 2:454-466(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ED133Imported.

    Entry informationi

    Entry nameiD8HC02_STAAF
    AccessioniPrimary (citable) accession number: D8HC02
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3