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D8GYL3 (D8GYL3_BACAI) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Synonyms:ddl1 EMBL ADK03041.1
Ordered Locus Names:BACI_c02750 EMBL ADK03041.1
OrganismBacillus cereus var. anthracis (strain CI) [Complete proteome] [HAMAP] EMBL ADK03041.1
Taxonomic identifier637380 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain140 – 345206ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding173 – 22856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2991Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D8GYL3 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 2CE9B037BBFB3ED0

FASTA36140,153
        10         20         30         40         50         60 
MTKIKLGLLY GGKSAEHQVS LQTALAAIKA LNQDKFEIHP IYITEQGQWI RGERIEGEVA 

        70         80         90        100        110        120 
NVEVLKMSGA ENAISPLSLS TEIIPSANAE ENAIDVIFPL LHGPNGEDGT VQGLLELMNI 

       130        140        150        160        170        180 
PYVGNGVLAS AAGMDKVVMK NIFAEAGLKQ AKYASFIRSG WEKDRETAYE KVEEVLGYPC 

       190        200        210        220        230        240 
FVKPANLGSS VGINKCKNRE ELENAFEEAF QFDRKIIVEE NIIGREVEVG VLGNDEPKCS 

       250        260        270        280        290        300 
VVGEIVPKKD FYDYKSKYID GDTALIIPAE RTEEESNVIK RDAIVAFQSL DGAGLTRADF 

       310        320        330        340        350        360 
FLTKDGEVYI NEVNTMPGFT PFSMFPLLWQ HTGLPYPELI EELIRLAMER HEEKQKIKYT 


I 

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References

[1]"The genome of a Bacillus isolate causing anthrax in chimpanzees combines chromosomal properties of B. cereus with B. anthracis virulence plasmids."
Klee S.R., Brzuszkiewicz E.B., Nattermann H., Bruggemann H., Dupke S., Wollherr A., Franz T., Pauli G., Appel B., Liebl W., Couacy-Hymann E., Boesch C., Meyer F.D., Leendertz F.H., Ellerbrok H., Gottschalk G., Grunow R., Liesegang H.
PLoS ONE 5:E10986-E10986(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CI EMBL ADK03041.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001746 Genomic DNA. Translation: ADK03041.1.
RefSeqYP_003790179.1. NC_014335.1.

3D structure databases

ProteinModelPortalD8GYL3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADK03041; ADK03041; BACI_c02750.
GeneID9452800.
KEGGbal:BACI_c02750.
PATRIC42175097. VBIBacCer111781_0565.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.

Enzyme and pathway databases

BioCycBCER637380:GHO7-268-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8GYL3_BACAI
AccessionPrimary (citable) accession number: D8GYL3
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)