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Protein

Aldehyde-alcohol dehydrogenase

Gene

adhE1

Organism
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: InterPro
  2. alcohol dehydrogenase (NAD) activity Source: InterPro
  3. metal ion binding Source: InterPro

GO - Biological processi

  1. alcohol metabolic process Source: InterPro
  2. carbon utilization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

BioCyciCLJU748727:GHMO-1651-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde-alcohol dehydrogenaseUniRule annotation
Gene namesi
Name:adhE1Imported
Ordered Locus Names:CLJU_c16510Imported
OrganismiClostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)Imported
Taxonomic identifieri748727 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001656 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD8GU52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000025256.
KOiK04072.
OMAiIKAREKM.

Family and domain databases

Gene3Di3.40.309.10. 2 hits.
3.40.605.10. 1 hit.
InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012079. Bifunc_Ald-ADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF00465. Fe-ADH. 1 hit.
[Graphical view]
PIRSFiPIRSF000111. ALDH_ADH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8GU52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTNVEELM KRLEEIKDAQ KKFATYTQEQ VDEIFRQAAM AANSARIELA
60 70 80 90 100
KMAVEESGMG IVEDKVIKNH FASEYIYNKY KDEKTCGVLE RDAGFGIVRI
110 120 130 140 150
AEPVGVIAAV VPTTNPTSTA IFKSLIALKT RNGIIFSPHP RAKKSTIAAA
160 170 180 190 200
KIVLDAAVKA GAPEGIIGWI DEPSIELSQV VMGEANLILA TGGPGMVKAA
210 220 230 240 250
YSSGKPAVGV GPGNTPAVID ESADIKMAVN SILLSKTFDN GMICASEQSV
260 270 280 290 300
IVLDSIYEEV KKEFAYRGAY ILSKDETDKV GKIILKNGAL NAGIVGQPAF
310 320 330 340 350
KIAQLAGVDV PEKAKVLIGE VESVELEEPF SHEKLSPVLA MYRARNFEDA
360 370 380 390 400
IAKTDKLVRS GGFGHTSSLY VNPMTEKAKV EKFSTMMKTS RTIINTPSSQ
410 420 430 440 450
GGIGDIYNFK LAPSLTLGCG SWGGNSVSEN VGPKHLLNIK SVAERRENML
460 470 480 490 500
WFRVPEKVYF KYGSLGVALK ELKVMNKKKV FIVTDKVLYQ LGYVDKVTKV
510 520 530 540 550
LEELKISYKV FTDVEPDPTL ATAKKGAAEL LSYEPDTIIS VGGGSAMDAA
560 570 580 590 600
KIMWVMYEHP EVKFEDLAMR FMDIRKRVYV FPKMGEKAMM ISVATSAGTG
610 620 630 640 650
SEVTPFAVIT DEKTGAKYPL ADYELTPDMA IVDAELMMGM PRGLTAASGI
660 670 680 690 700
DALTHALEAY VSIMATEFTN GLALEAVKLI FEYLPKAYTE GTTNVKAREK
710 720 730 740 750
MVHASCIAGM AFANAFLGVC HSMAHKLGAQ HHIPHGIANA LMIDEVIKFN
760 770 780 790 800
AVDDPIKQAA FPQYEYPNAR YRYAQIADCL NLGGNTEEEK VQLLINAIDD
810 820 830 840 850
LKAKLNIPET IKEAGVSEDK FYATLDKMSE LAFDDQCTGA NPRYPLISEI
860 870
KQMYINVFDK TEPIVEDEEK
Length:870
Mass (Da):95,020
Last modified:October 5, 2010 - v1
Checksum:i25F4999DEA6A5A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001666 Genomic DNA. Translation: ADK14715.1.
RefSeqiYP_003779817.1. NC_014328.1.

Genome annotation databases

EnsemblBacteriaiADK14715; ADK14715; CLJU_c16510.
KEGGiclj:CLJU_c16510.
PATRICi42484522. VBICloLju82977_1628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001666 Genomic DNA. Translation: ADK14715.1.
RefSeqiYP_003779817.1. NC_014328.1.

3D structure databases

ProteinModelPortaliD8GU52.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK14715; ADK14715; CLJU_c16510.
KEGGiclj:CLJU_c16510.
PATRICi42484522. VBICloLju82977_1628.

Phylogenomic databases

HOGENOMiHOG000025256.
KOiK04072.
OMAiIKAREKM.

Enzyme and pathway databases

BioCyciCLJU748727:GHMO-1651-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 2 hits.
3.40.605.10. 1 hit.
InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012079. Bifunc_Ald-ADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF00465. Fe-ADH. 1 hit.
[Graphical view]
PIRSFiPIRSF000111. ALDH_ADH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55383 / DSM 13528 / PETCImported.

Entry informationi

Entry nameiD8GU52_CLOLD
AccessioniPrimary (citable) accession number: D8GU52
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 1, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.