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D8GRD1

- D8GRD1_CLOLD

UniProt

D8GRD1 - D8GRD1_CLOLD

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Protein

Alanine racemase

Gene

alr1

Organism
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCLJU748727:GHMO-1201-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1Imported
Ordered Locus Names:CLJU_c12010Imported
OrganismiClostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)Imported
Taxonomic identifieri748727 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001656: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD8GRD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiMNLDMVR.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8GRD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRNYRPVWA EVNLDNLAYN MRNIKAQTMT KEIFGVVKAD AYGHGALEVS
60 70 80 90 100
KVLLENGATR LSVAVLSEGI ELRKGGITCP INILGVTPST LFPDLIGYSL
110 120 130 140 150
EPVVFSYEYA KSLSEYANSK NKKVKVHLAV DSGMGRIGFL PTEHNVEEAV
160 170 180 190 200
KISKISNIEI ESVFSHFSTA DEKDKKYSKF QFDKYRWFVN ELKEKGLNIK
210 220 230 240 250
IRDISNSAAI VDLPETYCDG VRPGIILYGY YPSDEVDKSR LDIKPVMTLK
260 270 280 290 300
ASVVYLKTLN EGQYVGYGRR FKTERRTVIA TLPVGYADGY TRILSGKLKV
310 320 330 340 350
IINGKLAPVI GNICMDQCMI DVTDIEDVKI GDEVILMGSD GKVKFDAEDI
360 370 380
AKLLGTISYE VLCMVNKRVP RVYIKNGHVI KVKNYI
Length:386
Mass (Da):43,229
Last modified:October 5, 2010 - v1
Checksum:i25D0AC1342FE942A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001666 Genomic DNA. Translation: ADK14269.1.
RefSeqiWP_013237866.1. NC_014328.1.
YP_003779371.1. NC_014328.1.

Genome annotation databases

EnsemblBacteriaiADK14269; ADK14269; CLJU_c12010.
GeneIDi9444818.
KEGGiclj:CLJU_c12010.
PATRICi42483600. VBICloLju82977_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001666 Genomic DNA. Translation: ADK14269.1 .
RefSeqi WP_013237866.1. NC_014328.1.
YP_003779371.1. NC_014328.1.

3D structure databases

ProteinModelPortali D8GRD1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADK14269 ; ADK14269 ; CLJU_c12010 .
GeneIDi 9444818.
KEGGi clj:CLJU_c12010.
PATRICi 42483600. VBICloLju82977_1170.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi MNLDMVR.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CLJU748727:GHMO-1201-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55383 / DSM 13528 / PETCImported.

Entry informationi

Entry nameiD8GRD1_CLOLD
AccessioniPrimary (citable) accession number: D8GRD1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3