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D8GRD1

- D8GRD1_CLOLD

UniProt

D8GRD1 - D8GRD1_CLOLD

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Protein
Alanine racemase
Gene
alr1, CLJU_c12010
Organism
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei136 – 1361Substrate By similarityUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCLJU748727:GHMO-1201-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1Imported
Ordered Locus Names:CLJU_c12010Imported
OrganismiClostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)Imported
Taxonomic identifieri748727 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001656: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD8GRD1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiMNLDMVR.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8GRD1-1 [UniParc]FASTAAdd to Basket

« Hide

MFRNYRPVWA EVNLDNLAYN MRNIKAQTMT KEIFGVVKAD AYGHGALEVS    50
KVLLENGATR LSVAVLSEGI ELRKGGITCP INILGVTPST LFPDLIGYSL 100
EPVVFSYEYA KSLSEYANSK NKKVKVHLAV DSGMGRIGFL PTEHNVEEAV 150
KISKISNIEI ESVFSHFSTA DEKDKKYSKF QFDKYRWFVN ELKEKGLNIK 200
IRDISNSAAI VDLPETYCDG VRPGIILYGY YPSDEVDKSR LDIKPVMTLK 250
ASVVYLKTLN EGQYVGYGRR FKTERRTVIA TLPVGYADGY TRILSGKLKV 300
IINGKLAPVI GNICMDQCMI DVTDIEDVKI GDEVILMGSD GKVKFDAEDI 350
AKLLGTISYE VLCMVNKRVP RVYIKNGHVI KVKNYI 386
Length:386
Mass (Da):43,229
Last modified:October 5, 2010 - v1
Checksum:i25D0AC1342FE942A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001666 Genomic DNA. Translation: ADK14269.1.
RefSeqiWP_013237866.1. NC_014328.1.
YP_003779371.1. NC_014328.1.

Genome annotation databases

EnsemblBacteriaiADK14269; ADK14269; CLJU_c12010.
GeneIDi9444818.
KEGGiclj:CLJU_c12010.
PATRICi42483600. VBICloLju82977_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001666 Genomic DNA. Translation: ADK14269.1 .
RefSeqi WP_013237866.1. NC_014328.1.
YP_003779371.1. NC_014328.1.

3D structure databases

ProteinModelPortali D8GRD1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADK14269 ; ADK14269 ; CLJU_c12010 .
GeneIDi 9444818.
KEGGi clj:CLJU_c12010.
PATRICi 42483600. VBICloLju82977_1170.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi MNLDMVR.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CLJU748727:GHMO-1201-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55383 / DSM 13528 / PETC.

Entry informationi

Entry nameiD8GRD1_CLOLD
AccessioniPrimary (citable) accession number: D8GRD1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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