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D8GRD1 (D8GRD1_CLOLD) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 RuleBase RU004247 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201 RuleBase RU004247

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site381Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2671Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1361Substrate By similarity HAMAP-Rule MF_01201
Binding site3151Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue381N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
D8GRD1 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 25D0AC1342FE942A

FASTA38643,229
        10         20         30         40         50         60 
MFRNYRPVWA EVNLDNLAYN MRNIKAQTMT KEIFGVVKAD AYGHGALEVS KVLLENGATR 

        70         80         90        100        110        120 
LSVAVLSEGI ELRKGGITCP INILGVTPST LFPDLIGYSL EPVVFSYEYA KSLSEYANSK 

       130        140        150        160        170        180 
NKKVKVHLAV DSGMGRIGFL PTEHNVEEAV KISKISNIEI ESVFSHFSTA DEKDKKYSKF 

       190        200        210        220        230        240 
QFDKYRWFVN ELKEKGLNIK IRDISNSAAI VDLPETYCDG VRPGIILYGY YPSDEVDKSR 

       250        260        270        280        290        300 
LDIKPVMTLK ASVVYLKTLN EGQYVGYGRR FKTERRTVIA TLPVGYADGY TRILSGKLKV 

       310        320        330        340        350        360 
IINGKLAPVI GNICMDQCMI DVTDIEDVKI GDEVILMGSD GKVKFDAEDI AKLLGTISYE 

       370        380 
VLCMVNKRVP RVYIKNGHVI KVKNYI 

« Hide

References

[1]"Clostridium ljungdahlii represents a microbial production platform based on syngas."
Kopke M., Held C., Hujer S., Liesegang H., Wiezer A., Wollherr A., Ehrenreich A., Liebl W., Gottschalk G., Durre P.
Proc. Natl. Acad. Sci. U.S.A. 107:13087-13092(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 55383 / DSM 13528 / PETC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001666 Genomic DNA. Translation: ADK14269.1.
RefSeqYP_003779371.1. NC_014328.1.

3D structure databases

ProteinModelPortalD8GRD1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADK14269; ADK14269; CLJU_c12010.
GeneID9444818.
KEGGclj:CLJU_c12010.
PATRIC42483600. VBICloLju82977_1170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.
OMAMNLDMVR.

Enzyme and pathway databases

BioCycCLJU748727:GHMO-1201-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8GRD1_CLOLD
AccessionPrimary (citable) accession number: D8GRD1
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)