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D8GRD1

- D8GRD1_CLOLD

UniProt

D8GRD1 - D8GRD1_CLOLD

Protein

Alanine racemase

Gene

alr1

Organism
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCLJU748727:GHMO-1201-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr1Imported
    Ordered Locus Names:CLJU_c12010Imported
    OrganismiClostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)Imported
    Taxonomic identifieri748727 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001656: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD8GRD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiMNLDMVR.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D8GRD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRNYRPVWA EVNLDNLAYN MRNIKAQTMT KEIFGVVKAD AYGHGALEVS    50
    KVLLENGATR LSVAVLSEGI ELRKGGITCP INILGVTPST LFPDLIGYSL 100
    EPVVFSYEYA KSLSEYANSK NKKVKVHLAV DSGMGRIGFL PTEHNVEEAV 150
    KISKISNIEI ESVFSHFSTA DEKDKKYSKF QFDKYRWFVN ELKEKGLNIK 200
    IRDISNSAAI VDLPETYCDG VRPGIILYGY YPSDEVDKSR LDIKPVMTLK 250
    ASVVYLKTLN EGQYVGYGRR FKTERRTVIA TLPVGYADGY TRILSGKLKV 300
    IINGKLAPVI GNICMDQCMI DVTDIEDVKI GDEVILMGSD GKVKFDAEDI 350
    AKLLGTISYE VLCMVNKRVP RVYIKNGHVI KVKNYI 386
    Length:386
    Mass (Da):43,229
    Last modified:October 5, 2010 - v1
    Checksum:i25D0AC1342FE942A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001666 Genomic DNA. Translation: ADK14269.1.
    RefSeqiWP_013237866.1. NC_014328.1.
    YP_003779371.1. NC_014328.1.

    Genome annotation databases

    EnsemblBacteriaiADK14269; ADK14269; CLJU_c12010.
    GeneIDi9444818.
    KEGGiclj:CLJU_c12010.
    PATRICi42483600. VBICloLju82977_1170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001666 Genomic DNA. Translation: ADK14269.1 .
    RefSeqi WP_013237866.1. NC_014328.1.
    YP_003779371.1. NC_014328.1.

    3D structure databases

    ProteinModelPortali D8GRD1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADK14269 ; ADK14269 ; CLJU_c12010 .
    GeneIDi 9444818.
    KEGGi clj:CLJU_c12010.
    PATRICi 42483600. VBICloLju82977_1170.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi MNLDMVR.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CLJU748727:GHMO-1201-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 55383 / DSM 13528 / PETCImported.

    Entry informationi

    Entry nameiD8GRD1_CLOLD
    AccessioniPrimary (citable) accession number: D8GRD1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3