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Protein

Thioredoxin reductase

Gene

trxB_2

Organism
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADPUniRule annotation

Enzyme and pathway databases

BioCyciCLJU748727:GHMO-2780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductaseUniRule annotation (EC:1.8.1.9UniRule annotation)
Gene namesi
Name:trxB_2Imported
Ordered Locus Names:CLJU_c27810Imported
ORF Names:WX45_01152Imported
OrganismiClostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)Imported
Taxonomic identifieri748727 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001656 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi748727.CLJU_c27810.

Structurei

3D structure databases

ProteinModelPortaliD8GNH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 298294FAD/NAD-binding_domInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072911.
KOiK00384.
OMAiYFHELDE.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8GNH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNIYDVIII GSGPAGLSAA LYSARAKMKT LLLERSKAGG QIVITDEVAN
60 70 80 90 100
YPGSIKEATG PSLIARMEEQ VESFGAERKK DEIKEVDFTG KIKRLKGIKE
110 120 130 140 150
EYQAKAVIIA TGATPRHIGC PGENQLIGKG VSYCATCDAE FFEDLEVFVV
160 170 180 190 200
GGGDAAIEEA LYLTKFAKKV TIVHRRDELR AAKSIQEKAF KNPKVEIMWN
210 220 230 240 250
KVITELKGDG LLESAVFKDT KTGEINEYFA DEEDGTFGVF VFVGYLPING
260 270 280 290 300
LFKDKITMNK AGYIITNDKM ETNISGVFAA GDIREKPLRQ VVTAAADGAI
310
AAVEAGKYIE NNFEE
Length:315
Mass (Da):34,355
Last modified:October 5, 2010 - v1
Checksum:i89C718C33D247181
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001666 Genomic DNA. Translation: ADK15835.1.
LITS01000025 Genomic DNA. Translation: OAA84295.1.
RefSeqiWP_013239425.1. NZ_LITS01000025.1.

Genome annotation databases

EnsemblBacteriaiADK15835; ADK15835; CLJU_c27810.
KEGGiclj:CLJU_c27810.
PATRICi42486895. VBICloLju82977_2813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001666 Genomic DNA. Translation: ADK15835.1.
LITS01000025 Genomic DNA. Translation: OAA84295.1.
RefSeqiWP_013239425.1. NZ_LITS01000025.1.

3D structure databases

ProteinModelPortaliD8GNH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi748727.CLJU_c27810.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK15835; ADK15835; CLJU_c27810.
KEGGiclj:CLJU_c27810.
PATRICi42486895. VBICloLju82977_2813.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072911.
KOiK00384.
OMAiYFHELDE.

Enzyme and pathway databases

BioCyciCLJU748727:GHMO-2780-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Koepke M., Hujer S., Held C., Wiezer A., Liesegang H., Ehrenreich A., Gottschalk G., Duerre P.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 13528Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55383 / DSM 13528 / PETCImported and DSM 13528Imported.
  3. "Traits of selected Clostridium strains for syngas fermentation to ethanol."
    Martin M.E., Richter H., Saha S., Angenent L.T.
    Biotechnol. Bioeng. 113:531-539(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PETCImported.

Entry informationi

Entry nameiD8GNH2_CLOLD
AccessioniPrimary (citable) accession number: D8GNH2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 6, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.