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Protein

Xylose isomerase

Gene

xylA

Organism
Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101UniRule annotation1
Active sitei104UniRule annotation1
Metal bindingi232Magnesium 1UniRule annotation1
Metal bindingi268Magnesium 1UniRule annotation1
Metal bindingi268Magnesium 2UniRule annotation1
Metal bindingi271Magnesium 2UniRule annotation1
Metal bindingi296Magnesium 1UniRule annotation1
Metal bindingi307Magnesium 2UniRule annotation1
Metal bindingi309Magnesium 2UniRule annotation1
Metal bindingi339Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.5UniRule annotationSAAS annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:CLJU_c18240Imported
OrganismiClostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)Imported
Taxonomic identifieri748727 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001656 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi748727.CLJU_c18240.

Structurei

3D structure databases

ProteinModelPortaliD8GI25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8GI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEYFNNVSK INYEGPDSKN PYSFKYYNPD EVIGGKKMRD HLRFSMSYWH
60 70 80 90 100
TLTANGTDQF GSGTMVRPWD NVNDKMELAK ARMEAAFEFM NKLDIDYFCF
110 120 130 140 150
HDRDIAPEGK DLAETNKNLD EIVAMCKDLM KKNNKKLLWG TANLFNNPRF
160 170 180 190 200
VHGAGTTCNA NVYAYSAAQL KKAIEVTNEL GGENYVFWGG REGYETLLNT
210 220 230 240 250
DMGFEMDNFA RILQMAVDYA KKIGFKGQFL IEPKPKEPTK HQYDFDVATV
260 270 280 290 300
LGFLRKYKLE DYFKINIEAN HATLAGHTFQ HEICLARNNN ALGSLDANQG
310 320 330 340 350
DPHLGWDTDQ FPTNVYDTTL SMYEVLKNGG IAPGGLNFDA KVRRASFEPE
360 370 380 390 400
DLFLAYIAGM DSFAKGLRVA YKLLQDAPIE NFIKERYSSF STGIGKDIVD
410 420 430 440
GKVGFDELEK YALENNVINN KSGRQEYLES VVNQYILEDK
Length:440
Mass (Da):50,112
Last modified:October 5, 2010 - v1
Checksum:iA76171A640A04875
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001666 Genomic DNA. Translation: ADK14887.1.
RefSeqiWP_013238479.1. NZ_LITS01000007.1.

Genome annotation databases

EnsemblBacteriaiADK14887; ADK14887; CLJU_c18240.
KEGGiclj:CLJU_c18240.
PATRICi42484881. VBICloLju82977_1807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001666 Genomic DNA. Translation: ADK14887.1.
RefSeqiWP_013238479.1. NZ_LITS01000007.1.

3D structure databases

ProteinModelPortaliD8GI25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi748727.CLJU_c18240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK14887; ADK14887; CLJU_c18240.
KEGGiclj:CLJU_c18240.
PATRICi42484881. VBICloLju82977_1807.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD8GI25_CLOLD
AccessioniPrimary (citable) accession number: D8GI25
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.