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Protein

Alanine racemase

Gene

LCAZH_2523

Organism
Lactobacillus casei (strain Zhang)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei140 – 1401SubstrateUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLCAS498216:GH2S-2512-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:LCAZH_2523Imported
OrganismiLactobacillus casei (strain Zhang)Imported
Taxonomic identifieri498216 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001655: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD8GCQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8GCQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIGNFRPAK VLIDETAILH NIQHEVARLK KQTQLFAVVK ADAYGHGMLR
60 70 80 90 100
VARVAKAAGA TGFCVAILDE ALGLRKADYS EPVLVLGIVP SQYAAIAAAQ
110 120 130 140 150
TISLPVSSTE WLEQALPVLE AQPELPPLRI HLALDTGMGR IGFTEDQALK
160 170 180 190 200
TAVAFVEAHS KQFVIEGIFT HFATADAPDD TYFKQQVDKF NHLVDLLPSR
210 220 230 240 250
PRYVHVSNSA TSLWHAACNG NMIRYGVAIY GLNPSGDAIP TTPFPLEPAL
260 270 280 290 300
SLESELTYCK QVHAGDGISY GVTYRAKGDE FIGTVPIGYA DGWLRRLQGF
310 320 330 340 350
HVLVDGQYCE IVGRICMDQF MIRLPKAYPA GTKVVLVGQS GDQEITLLDV
360 370
AKYSKTIHYE IACNLTPRLK RQSVNPVD
Length:378
Mass (Da):41,332
Last modified:October 5, 2010 - v1
Checksum:i3D6D3A712D7A5CAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001084 Genomic DNA. Translation: ADK19714.1.
RefSeqiYP_003789564.1. NC_014334.1.

Genome annotation databases

EnsemblBacteriaiADK19714; ADK19714; LCAZH_2523.
GeneIDi9460432.
KEGGilcz:LCAZH_2523.
PATRICi42380842. VBILacCas45142_2367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001084 Genomic DNA. Translation: ADK19714.1.
RefSeqiYP_003789564.1. NC_014334.1.

3D structure databases

ProteinModelPortaliD8GCQ2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADK19714; ADK19714; LCAZH_2523.
GeneIDi9460432.
KEGGilcz:LCAZH_2523.
PATRICi42380842. VBILacCas45142_2367.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciLCAS498216:GH2S-2512-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Meng H.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Zhang.
  2. "Complete genome sequence of Lactobacillus casei Zhang, a new probiotic strain isolated from traditional home-made koumiss in Inner Mongolia of China."
    Zhang W., Yu D., Sun Z., Wu R., Chen X., Chen W., Meng H., Hu S., Zhang H.
    J. Bacteriol. 192:5268-5269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZhangImported.

Entry informationi

Entry nameiD8GCQ2_LACCZ
AccessioniPrimary (citable) accession number: D8GCQ2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: February 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.