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Protein
Submitted name:

Interleukin 6

Gene

IL-6

Organism
Syncerus caffer (African buffalo)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 6Imported
Gene namesi
Name:IL-6Imported
OrganismiSyncerus caffer (African buffalo)Imported
Taxonomic identifieri9970 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeSyncerus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500310683726 – 208Sequence analysisAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 78UniRule annotation
Disulfide bondi101 ↔ 111UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili126 – 146Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
PANTHERiPTHR45110. PTHR45110. 1 hit.
PfamiView protein in Pfam
PF00489. IL6. 1 hit.
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiView protein in SMART
SM00126. IL6. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00254. INTERLEUKIN_6. 1 hit.

Sequencei

Sequence statusi: Complete.

D7UU01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSRFTSAFT PFAVSLGLLL VMTSAFPTPG PLGEDFKNDT TPGRLLLTTP
60 70 80 90 100
EKTEALIKRM VDKISAMRKE ICEKNDECES SKDTLAENKL NLPKMEEKDG
110 120 130 140 150
CFQSGFNQAI CLIRTTAGLL EYQIYLDYLQ NEYEGNRENV RDLRKNIRTL
160 170 180 190 200
IQILKQKIED LITTPATNTD LLEKMQSSNE WVKNAKIILI LRNLENFLQF

SLRAIRMK
Length:208
Mass (Da):23,831
Last modified:October 5, 2010 - v1
Checksum:i0C38181974EE7342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB571652 mRNA. Translation: BAJ11608.1.

Similar proteinsi

Entry informationi

Entry nameiD7UU01_SYNCA
AccessioniPrimary (citable) accession number: D7UU01
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: December 20, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)