ID D7RIH8_HUMAN Unreviewed; 266 AA. AC D7RIH8; G0YWD3; DT 10-AUG-2010, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 1. DT 27-MAR-2024, entry version 106. DE SubName: Full=HLA class II histocompatibility antigen DR beta chain {ECO:0000313|EMBL:BBD34128.1}; DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:QIJ58246.1}; DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:ADI59573.1}; GN Name=HLA-DRB1 {ECO:0000313|EMBL:ADI59573.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADI59573.1}; RN [1] {ECO:0000313|EMBL:ADI59573.1} RP NUCLEOTIDE SEQUENCE. RA Zhu F.M., He Y.M., Yan L.X.; RT "Full length cDNA sequence of HLA-DRB1*15:01:01:01."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ADI59573.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21388356; DOI=10.1111/j.1399-0039.2010.01626.x; RA Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.; RT "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group- RT specific amplification primers in the Chinese Han population."; RL Tissue Antigens 77:329-332(2011). RN [3] {ECO:0000313|EMBL:AEV76920.1} RP NUCLEOTIDE SEQUENCE. RA Xu Y., Deng Z., Yang B.; RT "Characterization and polymorphism analyses of HLA-DRB1 genomic full length RT in Chinese Han population."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AEK27140.2} RP NUCLEOTIDE SEQUENCE. RA Xu Y.P., Deng Z.H., Yang B.C.; RT "Characterization and polymorphism analyses of HLA-DRB1 genomic full length RT in Chinese Han population."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:BBD34128.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30337930; DOI=.3389/fimmu.2018.02294; RA Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., Oka A., RA Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., Morishima S., RA Morishima Y., Inoko H., Kulski J.K., Shiina T.; RT "Reference Grade Characterization of Polymorphisms in Full-Length HLA Class RT I and II Genes With Short-Read Sequencing on the ION PGM System and Long- RT Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio RT Platform."; RL Front. Immunol. 9:2294-2294(2018). RN [6] {ECO:0000313|EMBL:QIJ58246.1} RP NUCLEOTIDE SEQUENCE. RA Lazaro A., Hou L.; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:CAD0297740.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM067861; ADI59573.1; -; mRNA. DR EMBL; HQ840743; AEK27140.2; -; Genomic_DNA. DR EMBL; JN157603; AEV76920.1; -; Genomic_DNA. DR EMBL; LC257810; BBD34128.1; -; Genomic_DNA. DR EMBL; LC257811; BBD34129.1; -; Genomic_DNA. DR EMBL; LR828210; CAD0297740.1; -; Genomic_DNA. DR EMBL; LR828213; CAD0297743.1; -; Genomic_DNA. DR EMBL; LR828216; CAD0297746.1; -; Genomic_DNA. DR EMBL; LR828225; CAD0297755.1; -; Genomic_DNA. DR EMBL; LR828226; CAD0297756.1; -; Genomic_DNA. DR EMBL; LR828227; CAD0297757.1; -; Genomic_DNA. DR EMBL; LR828228; CAD0297758.1; -; Genomic_DNA. DR EMBL; LR828235; CAD0297765.1; -; Genomic_DNA. DR EMBL; LR828244; CAD0297774.1; -; Genomic_DNA. DR EMBL; LR828246; CAD0297776.1; -; Genomic_DNA. DR EMBL; LR828247; CAD0297777.1; -; Genomic_DNA. DR EMBL; LR828249; CAD0297779.1; -; Genomic_DNA. DR EMBL; LR828250; CAD0297780.1; -; Genomic_DNA. DR EMBL; MT124679; QIJ58246.1; -; Genomic_DNA. DR RefSeq; NP_002115.2; NM_002124.3. DR AlphaFoldDB; D7RIH8; -. DR SMR; D7RIH8; -. DR Antibodypedia; 4207; 1103 antibodies from 36 providers. DR DNASU; 3123; -. DR GeneID; 3123; -. DR CTD; 3123; -. DR VEuPathDB; HostDB:ENSG00000196126; -. DR HOGENOM; CLU_047501_13_1_1; -. DR OMA; PKRECHF; -. DR OrthoDB; 3785866at2759; -. DR BioGRID-ORCS; 3123; 23 hits in 1057 CRISPR screens. DR ChiTaRS; HLA-DRB1; human. DR GenomeRNAi; 3123; -. DR ExpressionAtlas; D7RIH8; baseline and differential. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR CDD; cd21000; IgC1_MHC_II_beta_HLA-DR; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF107; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 4 CHAIN-RELATED; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..29 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 30..266 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014302684" FT TRANSMEM 228..250 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 126..214 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" SQ SEQUENCE 266 AA; 29966 MW; 3B5912820A4654BE CRC64; MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA RAAVDTYCRH NYGVVESFTV QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF RNQKGHSGLQ PTGFLS //