D7RIH8 (D7RIH8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MHC class II antigen EMBL ADI59573.1

Gene names

Name:

HLA-DRB1 EMBL ADI59573.1

Organism

Homo sapiens (Human) EMBL ADI59573.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS003597

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC II RuleBase RU000321 SAAS SAAS003597 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS014745
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D7RIH8 [UniParc]. Last modified August 10, 2010. Version 1. Checksum: 3B5912820A4654BE	FASTA	266	29,966
	10 20 30 40 50 60 MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF 70 80 90 100 110 120 YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA RAAVDTYCRH NYGVVESFTV 130 140 150 160 170 180 QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PTGFLS

References

[1]	"Full length cDNA sequence of HLA-DRB1*15:01:01:01." Zhu F.M., He Y.M., Yan L.X. Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population." Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L. Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Characterization and polymorphism analyses of HLA-DRB1 genomic full length in Chinese Han population." Xu Y., Deng Z., Yang B. Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Characterization and polymorphism analyses of HLA-DRB1 genomic full length in Chinese Han population." Xu Y.P., Deng Z.H., Yang B.C. Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HM067861 mRNA. Translation: ADI59573.1. HQ840743 Genomic DNA. Translation: AEK27140.2. JN157603 Genomic DNA. Translation: AEV76920.1.
IPI	IPI00472169.
RefSeq	NP_002115.2. NM_002124.3.
UniGene	Hs.534322. Hs.696211. Hs.736560.
3D structure databases
ProteinModelPortal	D7RIH8.
ModBase	Search...
Proteomic databases
PRIDE	D7RIH8.
Protocols and materials databases
DNASU	3123.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3123.
KEGG	hsa:3123.
Organism-specific databases
CTD	3123.
Phylogenomic databases
KO	K06752.
OMA	PITVEWX.
PhylomeDB	D7RIH8.
Gene expression databases
ArrayExpress	D7RIH8.
Bgee	D7RIH8.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDom	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-DRB1. human.
GenomeRNAi	3123.
NextBio	12394.

Entry information

Entry name

D7RIH8_HUMAN

Accession

Primary (citable) accession number: D7RIH8
Secondary accession number(s): G0YWD3

Entry history

Integrated into UniProtKB/TrEMBL:	August 10, 2010
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.