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D7RIH8

- D7RIH8_HUMAN

UniProt

D7RIH8 - D7RIH8_HUMAN

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Protein
Submitted name:

MHC class II antigen

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigenImported
Gene namesi
Name:HLA-DRB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotationSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

KOiK06752.
OMAiERISCGI.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7RIH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT
60 70 80 90 100
ERVRFLDRYF YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA
110 120 130 140 150
RAAVDTYCRH NYGVVESFTV QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):29,966
Last modified:August 10, 2010 - v1
Checksum:i3B5912820A4654BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM067861 mRNA. Translation: ADI59573.1.
HQ840743 Genomic DNA. Translation: AEK27140.2.
JN157603 Genomic DNA. Translation: AEV76920.1.
RefSeqiNP_002115.2. NM_002124.3.
UniGeneiHs.534322.
Hs.696211.
Hs.736560.

Genome annotation databases

GeneIDi3123.
KEGGihsa:3123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM067861 mRNA. Translation: ADI59573.1 .
HQ840743 Genomic DNA. Translation: AEK27140.2 .
JN157603 Genomic DNA. Translation: AEV76920.1 .
RefSeqi NP_002115.2. NM_002124.3.
UniGenei Hs.534322.
Hs.696211.
Hs.736560.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 3123.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3123.
KEGGi hsa:3123.

Organism-specific databases

CTDi 3123.

Phylogenomic databases

KOi K06752.
OMAi ERISCGI.

Miscellaneous databases

ChiTaRSi HLA-DRB1. human.
GenomeRNAii 3123.
NextBioi 12394.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full length cDNA sequence of HLA-DRB1*15:01:01:01."
    Zhu F.M., He Y.M., Yan L.X.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population."
    Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.
    Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Characterization and polymorphism analyses of HLA-DRB1 genomic full length in Chinese Han population."
    Xu Y., Deng Z., Yang B.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Characterization and polymorphism analyses of HLA-DRB1 genomic full length in Chinese Han population."
    Xu Y.P., Deng Z.H., Yang B.C.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD7RIH8_HUMAN
AccessioniPrimary (citable) accession number: D7RIH8
Secondary accession number(s): G0YWD3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.