ID D7RIG5_HUMAN Unreviewed; 266 AA. AC D7RIG5; DT 10-AUG-2010, integrated into UniProtKB/TrEMBL. DT 10-AUG-2010, sequence version 1. DT 27-MAR-2024, entry version 90. DE SubName: Full=HLA class II histocompatibility antigen DR beta chain {ECO:0000313|EMBL:BBD34102.1}; DE SubName: Full=HLA class II histocompatibility antigen, DRB1 beta chain {ECO:0000313|Ensembl:ENSP00000405960.2}; DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:ADI59560.1, ECO:0000313|EMBL:QIJ70731.1}; GN Name=HLA-DRB1 {ECO:0000313|EMBL:ADI59560.1, GN ECO:0000313|Ensembl:ENSP00000405960.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADI59560.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000405960.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:ADI59560.1} RP NUCLEOTIDE SEQUENCE. RA Zhu F.M., He Y.M., Yan L.X.; RT "Full length cDNA sequence of HLA-DRB1*07:01:01:01."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ADI59560.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21388356; DOI=10.1111/j.1399-0039.2010.01626.x; RA Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.; RT "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group- RT specific amplification primers in the Chinese Han population."; RL Tissue Antigens 77:329-332(2011). RN [4] {ECO:0000313|EMBL:CZQ50740.1} RP NUCLEOTIDE SEQUENCE. RA Oliw E.H.; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:CZQ50740.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BBD34102.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30337930; DOI=.3389/fimmu.2018.02294; RA Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., Oka A., RA Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., Morishima S., RA Morishima Y., Inoko H., Kulski J.K., Shiina T.; RT "Reference Grade Characterization of Polymorphisms in Full-Length HLA Class RT I and II Genes With Short-Read Sequencing on the ION PGM System and Long- RT Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio RT Platform."; RL Front. Immunol. 9:2294-2294(2018). RN [7] {ECO:0000313|EMBL:QIJ70731.1} RP NUCLEOTIDE SEQUENCE. RA Gervais T.G.; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:CAE2821794.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.; RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|Ensembl:ENSP00000405960.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. RN [10] {ECO:0007829|PDB:7Z0Q} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 31-228, AND DISULFIDE BONDS. RX PubMed=37142807; DOI=10.1038/s41589-023-01316-3; RA Abualrous E.T., Stolzenberg S., Sticht J., Wieczorek M., Roske Y., RA Gunther M., Dahn S., Boesen B.B., Calvo M.M., Biese C., Kuppler F., RA Medina-Garcia A., Alvaro-Benito M., Hofer T., Noe F., Freund C.; RT "MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed RT peptide exchange."; RL Nat. Chem. Biol. 19:1196-1204(2023). CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR753309; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753835; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; HM067848; ADI59560.1; -; mRNA. DR EMBL; LC257784; BBD34102.1; -; Genomic_DNA. DR EMBL; LR999434; CAE2821794.1; -; Genomic_DNA. DR EMBL; LT220254; CZQ50740.1; -; Genomic_DNA. DR EMBL; MT038391; QIJ70731.1; -; Genomic_DNA. DR RefSeq; XP_011546040.1; XM_011547738.2. DR PDB; 7Z0Q; X-ray; 2.10 A; D=31-228. DR SMR; D7RIG5; -. DR MassIVE; D7RIG5; -. DR Ensembl; ENST00000437784.6; ENSP00000405960.2; ENSG00000229074.8. DR Ensembl; ENST00000444645.6; ENSP00000409322.2; ENSG00000236884.8. DR HGNC; HGNC:4948; HLA-DRB1. DR BioGRID-ORCS; 3123; 23 hits in 1057 CRISPR screens. DR ChiTaRS; HLA-DRB1; human. DR GenomeRNAi; 3123; -. DR Proteomes; UP000005640; Unplaced. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR CDD; cd21000; IgC1_MHC_II_beta_HLA-DR; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF99; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 3 CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:7Z0Q}; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Proteomics identification {ECO:0007829|MaxQB:D7RIG5, KW ECO:0007829|PeptideAtlas:D7RIG5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..29 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 30..266 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014302683" FT TRANSMEM 228..250 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 126..216 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DISULFID 44..108 FT /evidence="ECO:0007829|PDB:7Z0Q" FT DISULFID 146..202 FT /evidence="ECO:0007829|PDB:7Z0Q" SQ SEQUENCE 266 AA; 29822 MW; 439B6AFA553F162C CRC64; MVCLKLPGGS CMAALTVTLM VLSSPLALAG DTQPRFLWQG KYKCHFFNGT ERVQFLERLF YNQEEFVRFD SDVGEYRAVT ELGRPVAESW NSQKDILEDR RGQVDTVCRH NYGVGESFTV QRRVHPEVTV YPAKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY TCQVEHPSVM SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF RNQKGHSGLQ PTGFLS //