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D7RIG5

- D7RIG5_HUMAN

UniProt

D7RIG5 - D7RIG5_HUMAN

Protein
Submitted name:

MHC class II antigen

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
    2. immune response Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class II antigenImported
    Gene namesi
    Name:HLA-DRB1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class II protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC IIUniRule annotationSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiD7RIG5.

    Structurei

    3D structure databases

    ProteinModelPortaliD7RIG5.
    SMRiD7RIG5. Positions 32-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    OMAiNGTERRY.
    PhylomeDBiD7RIG5.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7RIG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCLKLPGGS CMAALTVTLM VLSSPLALAG DTQPRFLWQG KYKCHFFNGT    50
    ERVQFLERLF YNQEEFVRFD SDVGEYRAVT ELGRPVAESW NSQKDILEDR 100
    RGQVDTVCRH NYGVGESFTV QRRVHPEVTV YPAKTQPLQH HNLLVCSVSG 150
    FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY 200
    TCQVEHPSVM SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
    RNQKGHSGLQ PTGFLS 266
    Length:266
    Mass (Da):29,822
    Last modified:August 10, 2010 - v1
    Checksum:i439B6AFA553F162C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM067848 mRNA. Translation: ADI59560.1.
    UniGeneiHs.696211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM067848 mRNA. Translation: ADI59560.1 .
    UniGenei Hs.696211.

    3D structure databases

    ProteinModelPortali D7RIG5.
    SMRi D7RIG5. Positions 32-219.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi D7RIG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi NGTERRY.
    PhylomeDBi D7RIG5.

    Miscellaneous databases

    ChiTaRSi HLA-DRB1. human.
    NextBioi 34054816.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full length cDNA sequence of HLA-DRB1*07:01:01:01."
      Zhu F.M., He Y.M., Yan L.X.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population."
      Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.
      Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD7RIG5_HUMAN
    AccessioniPrimary (citable) accession number: D7RIG5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.