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Protein
Submitted name:

MHC class II antigen

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigenImported
Gene namesi
Name:HLA-DRB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei228 – 250HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501193767930 – 266Sequence analysisAdd BLAST237

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 214Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328. MHC_II_b_N. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

D7RIG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCLKFPGGS CMAALTVTLM VLSSPLALAG DTRPRFLEQV KHECHFFNGT
60 70 80 90 100
ERVRFLDRYF YHQEEYVRFD SDVGEYRAVT ELGRPDAEYW NSQKDLLEQK
110 120 130 140 150
RAAVDTYCRH NYGVGESFTV QRRVYPEVTV YPAKTQPLQH HNLLVCSVNG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSLT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):30,112
Last modified:August 10, 2010 - v1
Checksum:i8116E91DA38294E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM067845 mRNA. Translation: ADI59557.1.
KJ657694 Genomic DNA. Translation: AHW47920.1.
KJ657696 Genomic DNA. Translation: AHW47954.1.
KJ657697 Genomic DNA. Translation: AHW47971.1.
LT220230 Genomic DNA. Translation: CZQ50716.1.
LT220246 Genomic DNA. Translation: CZQ50732.1.
LT220248 Genomic DNA. Translation: CZQ50734.1.
UniGeneiHs.534322.
Hs.696211.
Hs.736560.

Similar proteinsi

Entry informationi

Entry nameiD7RIG2_HUMAN
AccessioniPrimary (citable) accession number: D7RIG2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: January 31, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.