D7PBN4 (D7PBN4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: SLC45A3-BRAF fusion protein EMBL ADH51735.1
Organism	Homo sapiens (Human) EMBL ADH51735.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Gene Ontology (GO)
Biological_process	response to epidermal growth factor stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D7PBN4 [UniParc]. Last modified August 10, 2010. Version 1. Checksum: 93913670A7DEAB2C	FASTA	329	37,132
	10 20 30 40 50 60 MKTLGRRDSS DDWEIPDGQI TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA 70 80 90 100 110 120 FKNEVGVLRK TRHVNILLFM GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA 130 140 150 160 170 180 RQTAQGMDYL HAKSIIHRDL KSNNIFLHED LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI 190 200 210 220 230 240 LWMAPEVIRM QDKNPYSFQS DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD 250 260 270 280 290 300 LSKVRSNCPK AMKRLMAECL KKKRDERPLF PQILASIELL ARSLPKIHRS ASEPSLNRAG 310 320 FQTEDFSLYA CASPKTPIQA GGYGAFPVH

References

[1]

"Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer, and melanoma." Palanisamy N., Ateeq B., Kalyana-Sundaram S., Pflueger D., Ramnarayanan K., Shanker S., Han B., Cao Q., Cao X., Suleman K., Kumar-Sinha C., Dhanasekaran S.M., Chen Y.-B., Esgueva R., Banerjee S., LaFargue C.J., Siddiqui J., Demichelis F. , Moeller P., Bismar T.A., Kuefer R., Fullen D.R., Johnson T.M., Greenson J.K., Giordano T.J., Tan P., Tomlins S.A., Varambally S., Rubin M.A., Maher C.A., Chinnaiyan A.M. Nat. Med. 0:0-0(2010) Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GU149303 mRNA. Translation: ADH51735.1.
3D structure databases
ProteinModelPortal	D7PBN4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	D7PBN4.
Bgee	D7PBN4.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	D7PBN4.
NextBio	35495686.

Entry information

Entry name

D7PBN4_HUMAN

Accession

Primary (citable) accession number: D7PBN4

Entry history

Integrated into UniProtKB/TrEMBL:	August 10, 2010
Last sequence update:	August 10, 2010
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.