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D7PBN4

- D7PBN4_HUMAN

UniProt

D7PBN4 - D7PBN4_HUMAN

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Protein
Submitted name:

SLC45A3-BRAF fusion protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. MAP kinase kinase kinase activity Source: Ensembl

GO - Biological processi

  1. CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  2. cellular response to drug Source: Ensembl
  3. long-term synaptic potentiation Source: Ensembl
  4. myeloid progenitor cell differentiation Source: Ensembl
  5. negative regulation of endothelial cell apoptotic process Source: Ensembl
  6. negative regulation of fibroblast migration Source: Ensembl
  7. negative regulation of neuron apoptotic process Source: Ensembl
  8. negative regulation of synaptic vesicle exocytosis Source: Ensembl
  9. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  10. positive regulation of stress fiber assembly Source: Ensembl
  11. positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
  12. positive T cell selection Source: Ensembl
  13. protein heterooligomerization Source: Ensembl
  14. regulation of cell proliferation Source: Ensembl
  15. response to cAMP Source: Ensembl
  16. response to epidermal growth factor Source: Ensembl
  17. response to peptide hormone Source: Ensembl
  18. somatic stem cell maintenance Source: Ensembl
  19. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
SLC45A3-BRAF fusion proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. neuron projection Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD7PBN4.
ExpressionAtlasiD7PBN4. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliD7PBN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7PBN4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLGRRDSS DDWEIPDGQI TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV
60 70 80 90 100
TAPTPQQLQA FKNEVGVLRK TRHVNILLFM GYSTKPQLAI VTQWCEGSSL
110 120 130 140 150
YHHLHIIETK FEMIKLIDIA RQTAQGMDYL HAKSIIHRDL KSNNIFLHED
160 170 180 190 200
LTVKIGDFGL ATVKSRWSGS HQFEQLSGSI LWMAPEVIRM QDKNPYSFQS
210 220 230 240 250
DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK
260 270 280 290 300
AMKRLMAECL KKKRDERPLF PQILASIELL ARSLPKIHRS ASEPSLNRAG
310 320
FQTEDFSLYA CASPKTPIQA GGYGAFPVH
Length:329
Mass (Da):37,132
Last modified:August 10, 2010 - v1
Checksum:i93913670A7DEAB2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU149303 mRNA. Translation: ADH51735.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU149303 mRNA. Translation: ADH51735.1 .

3D structure databases

ProteinModelPortali D7PBN4.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi D7PBN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

NextBioi 35495686.

Gene expression databases

Bgeei D7PBN4.
ExpressionAtlasi D7PBN4. baseline and differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD7PBN4_HUMAN
AccessioniPrimary (citable) accession number: D7PBN4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.