ID   D7MJV9_ARALL            Unreviewed;       476 AA.
AC   D7MJV9;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Proline dehydrogenase {ECO:0000256|ARBA:ARBA00012695, ECO:0000256|RuleBase:RU364054};
DE            EC=1.5.5.2 {ECO:0000256|ARBA:ARBA00012695, ECO:0000256|RuleBase:RU364054};
GN   ORFNames=ARALYDRAFT_494099 {ECO:0000313|EMBL:EFH47088.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC         quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC         ChEBI:CHEBI:132124; EC=1.5.5.2;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
CC       {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
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DR   EMBL; GL348719; EFH47088.1; -; Genomic_DNA.
DR   RefSeq; XP_002870829.1; XM_002870783.1.
DR   AlphaFoldDB; D7MJV9; -.
DR   STRING; 81972.D7MJV9; -.
DR   EnsemblPlants; fgenesh2_kg.7__3532__AT5G38710.1; fgenesh2_kg.7__3532__AT5G38710.1; fgenesh2_kg.7__3532__AT5G38710.1.
DR   Gramene; fgenesh2_kg.7__3532__AT5G38710.1; fgenesh2_kg.7__3532__AT5G38710.1; fgenesh2_kg.7__3532__AT5G38710.1.
DR   eggNOG; KOG0186; Eukaryota.
DR   HOGENOM; CLU_018202_3_0_1; -.
DR   OrthoDB; 5473051at2759; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblPlants.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006562; P:proline catabolic process; IEA:EnsemblPlants.
DR   GO; GO:0006970; P:response to osmotic stress; IEA:EnsemblPlants.
DR   GO; GO:0009414; P:response to water deprivation; IEA:EnsemblPlants.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914:SF31; PROLINE DEHYDROGENASE 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR   Pfam; PF01619; Pro_dh; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|RuleBase:RU364054};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU364054};
KW   Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW   ECO:0000256|RuleBase:RU364054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT   DOMAIN          133..456
FT                   /note="Proline dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF01619"
SQ   SEQUENCE   476 AA;  53145 MW;  6A53CD1B46C40CBC CRC64;
     MANRFLRPNL IHRFSTVSPV GPPTTVIPEI LSFDQPKQDV DLDLSDQARL FASVPISTLL
     RSTAVLHATS IGPMVDLGSW LMSSKLMDTT VTRDLILRVV KGTFYDHFCA GEDAAAAARR
     VSSMYESTGL KGMLVYGVEH AEDSGACDEN IQKFIETVEA AKTLPTSHLS SVVIKITAIC
     PMNLLKRVSD LLRWQYKNPN FKLPWKLNSF PVFSGLSPLY HTTSEPEPLT AEEERELEKA
     HERLKSVCKR CQESNVPLLI DAEDTILQPA IDYMAYWSAI MFNSDKDRPI VYNTIQAYLK
     DAGERLHLSL RESEKMNVPI GFKLVRGAYM SSEARLADSL GHKSPVHDTI QDTHNCYNDC
     MSFLMEKASN GSGIAVILAT HNTDSGKLGA RKASELGIDK ENGKIEFAQL YGMSDALSFG
     LKRAGFNVSK YMPYGPVDTA VPYLIRRAYE NRGMMSTGAL DRQLMRKELK RRVMGW
//