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Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial

Gene

ARALYDRAFT_910342

Organism
Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathway: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydroorotate dehydrogenase (quinone), mitochondrial (ARALYDRAFT_910342)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes orotate from (S)-dihydroorotate (quinone route), the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Flavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone), mitochondrialUniRule annotation (EC:1.3.5.2UniRule annotation)
Short name:
DHOdehaseUniRule annotation
Gene namesi
ORF Names:ARALYDRAFT_910342Imported
OrganismiArabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress)Imported
Taxonomic identifieri81972 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000008694 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi59689.scaffold_602399.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK00254.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7M1Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRAATSSA NWAREFLFRR VSSNPLGATR NCSSVPGASS APKVPHFSKK
60 70 80 90 100
GRILTGATIG LAIAGGAYVS TADEATFCGW LFNATKVVNP FFALLDAEFA
110 120 130 140 150
HKLAVSAAAR GWVPREKRPD PAILGLEVWG RKFSNPIGLA AGFDKNAEAT
160 170 180 190 200
EGLLGMGFGF VEVGSVTPVP QEGNPKPRIF RLSQEGAIIN RCGFNSEGIV
210 220 230 240 250
VVAKRLGAQH GKRMLAETSG TSSSPSDDVK PGGKSGPGIL GVNLGKNKTS
260 270 280 290 300
EDAAADYVQG VHNLSQYADY LVINVSSPNT AGLRMLQGRK QLKDLVKKVQ
310 320 330 340 350
AARDEMQWGD EGPPPLLVKI APDLSRGELE DIAAVALALH LDGLIISNTT
360 370 380 390 400
VSRPDPVSNN PVATEAGGLS GTPLFPLSTN MLRDMYTLTR GKIPLIGCGG
410 420 430 440 450
VSSGEDAYKK IRAGATLVQL YTGFAYGGPA LIPQIKEELV KCLERDGFKS
460
IHEAIGADHR
Length:460
Mass (Da):48,485
Last modified:August 10, 2010 - v1
Checksum:iA6ECCCA44FF469FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL348718 Genomic DNA. Translation: EFH50382.1.
RefSeqiXP_002874123.1. XM_002874077.1.

Genome annotation databases

EnsemblPlantsiscaffold_602399.1; scaffold_602399.1; scaffold_602399.1.
GeneIDi9308119.
KEGGialy:ARALYDRAFT_910342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL348718 Genomic DNA. Translation: EFH50382.1.
RefSeqiXP_002874123.1. XM_002874077.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59689.scaffold_602399.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiscaffold_602399.1; scaffold_602399.1; scaffold_602399.1.
GeneIDi9308119.
KEGGialy:ARALYDRAFT_910342.

Phylogenomic databases

KOiK00254.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. MN47Imported.

Entry informationi

Entry nameiD7M1Q4_ARALL
AccessioniPrimary (citable) accession number: D7M1Q4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.