ID   D7KGN8_ARALL            Unreviewed;       505 AA.
AC   D7KGN8;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=phosphomevalonate kinase {ECO:0000256|ARBA:ARBA00012958};
DE            EC=2.7.4.2 {ECO:0000256|ARBA:ARBA00012958};
GN   ORFNames=ARALYDRAFT_473379 {ECO:0000313|EMBL:EFH67215.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC       via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC       step 2/3. {ECO:0000256|ARBA:ARBA00005017}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase
CC       subfamily. {ECO:0000256|ARBA:ARBA00006495}.
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DR   EMBL; GL348713; EFH67215.1; -; Genomic_DNA.
DR   RefSeq; XP_002890956.1; XM_002890910.1.
DR   AlphaFoldDB; D7KGN8; -.
DR   STRING; 81972.D7KGN8; -.
DR   EnsemblPlants; fgenesh2_kg.1__3333__AT1G31910.1; fgenesh2_kg.1__3333__AT1G31910.1; fgenesh2_kg.1__3333__AT1G31910.1.
DR   Gramene; fgenesh2_kg.1__3333__AT1G31910.1; fgenesh2_kg.1__3333__AT1G31910.1; fgenesh2_kg.1__3333__AT1G31910.1.
DR   eggNOG; KOG4519; Eukaryota.
DR   HOGENOM; CLU_022059_1_0_1; -.
DR   OrthoDB; 991613at2759; -.
DR   UniPathway; UPA00057; UER00099.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:EnsemblPlants.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1.
DR   InterPro; IPR016005; Erg8.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR035102; Phosphomevalonate_kinase.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR01219; Pmev_kin_ERG8; 1.
DR   PANTHER; PTHR31814; -; 1.
DR   PANTHER; PTHR31814:SF2; PHOSPHOMEVALONATE KINASE; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF017288; PMK_GHMP_euk; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000313|EMBL:EFH67215.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW   Transferase {ECO:0000313|EMBL:EFH67215.1}.
FT   DOMAIN          180..249
FT                   /note="GHMP kinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00288"
FT   DOMAIN          398..469
FT                   /note="GHMP kinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08544"
SQ   SEQUENCE   505 AA;  54209 MW;  572B1A06BFB35887 CRC64;
     MAVVASAPGK VLMTGGYLVL DKPNAGLVLS TNARFYAIVK PINEDVKPES WAWKWTDVKL
     TSPQLSRESM FKLSLKHLTL QSVSASDSRN PFVEHAIQYA IAAAHLATDK DKEALHKLLL
     QGLDITILGS NDFYSYRNQI ESLGLPLTPE SLGTLAPFAS ITFNAAESNG ANSKPEVAKT
     GLGSSAAMTT AVVAALLHYL GVVDLSDPCK EGKFGCSDLD VIHMIAQTSH CLAQGKVGSG
     FDVSCAVYGS QRYVRFSPEV LSFAQVAVTG LPINEVIGTI LKGKWDHERT EFSLPPLMNL
     FLGEPGSGGS STPSMVGAVK KWQMSDPEKA RENWQKLSDA NLELETKLNV LSKLAKDHWD
     VYLGVIKSCS VLTSEKWVLH ATEPINEAII KELLEAREAM LRIRILMRQI GEAASVPIEP
     ESQTQLLDST MNAEGVLLAG VPGAGGFDAI FAITLGDSGS KLTQAWSSHN VLALLVREDP
     HGVCLESGDP RTTGITSGVS SILLV
//