ID   D7KB98_ARALL            Unreviewed;       672 AA.
AC   D7KB98;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=MEDEA {ECO:0008006|Google:ProtNLM};
GN   ORFNames=ARALYDRAFT_470218 {ECO:0000313|EMBL:EFH65667.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC         COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC         Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR   EMBL; GL348713; EFH65667.1; -; Genomic_DNA.
DR   RefSeq; XP_002889408.1; XM_002889362.1.
DR   AlphaFoldDB; D7KB98; -.
DR   STRING; 81972.D7KB98; -.
DR   EnsemblPlants; fgenesh2_kg.1__172__AT1G02580.1; fgenesh2_kg.1__172__AT1G02580.1; fgenesh2_kg.1__172__AT1G02580.1.
DR   Gramene; fgenesh2_kg.1__172__AT1G02580.1; fgenesh2_kg.1__172__AT1G02580.1; fgenesh2_kg.1__172__AT1G02580.1.
DR   eggNOG; KOG1079; Eukaryota.
DR   HOGENOM; CLU_011060_0_0_1; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR   GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:EnsemblPlants.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:EnsemblPlants.
DR   GO; GO:2000014; P:regulation of endosperm development; IEA:EnsemblPlants.
DR   GO; GO:0009646; P:response to absence of light; IEA:EnsemblPlants.
DR   GO; GO:0048317; P:seed morphogenesis; IEA:EnsemblPlants.
DR   CDD; cd10519; SET_EZH; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR045318; EZH1/2-like.
DR   InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR   InterPro; IPR041355; Pre-SET_CXC.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   PANTHER; PTHR45747:SF7; HISTONE-LYSINE N-METHYLTRANSFERASE MEDEA; 1.
DR   Pfam; PF18264; preSET_CXC; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01114; CXC; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS51576; SAM_MT43_EZ; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          411..515
FT                   /note="CXC"
FT                   /evidence="ECO:0000259|PROSITE:PS51633"
FT   DOMAIN          527..642
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          649..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          146..175
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   672 AA;  77246 MW;  2EEC36CB426AC74D CRC64;
     MEKDNHEDDG EDLPPDINQI KEQIEEERFL HIKKTFELRC IPSVAAHASH HQSFDLNQPL
     AEDDNEGDNK TLLSRMQNPL HHFSALSDSD TYEDQGCVFN KEAPLFPSVN LPVVEQLPRS
     LTWVFIKRHL MAESDSVIGK RQIYYLNGEA LELSSEEDEE DEEEDEEEAK KEKCEFSKDV
     DRFIWTVGQD YGLDDLVVQR ALAKFLEVEV SDILERYNEL KLKNDETVGE ASDLTSKTIT
     TAFQDFADRR HCRRCLIFDC HMHEKFEPEF RPSEDKSGLF ENEDREPCSE HCYLKVRSVT
     EADHAVDNDN SISNKNVVSD PNTTMWTPVE KDLYLKGVQI FGRNSCAITL NILRGLKTCL
     EVYNYMLEQD QCTMSLVLHK TTKTKNQVNK KVSRKGTRSV RKKSRLRKYA RYPPALKKTT
     NGEAKFYKHY SPCTCKSKCG YQCPCLTNEN CCEKYCGCPK DCNNRFGGCN CAIGQCTNRQ
     CPCFAANREC DPDLCRSCPL SCGDGSLGEP SEQIQCKNMH FLLKKNKKIL IGKSNVHGWG
     AFTPDSLKKN EFLGEYTGEL ITHEEANERG RVEDRIGSSY LFTLNDQLEI DARRYGNKFK
     FLNHSARPNC YAKLMIVRGD QRIGLFAERA IEQNEELFFD YCYGPEHADW SRGREPRKTG
     ASKRSKEARP SR
//