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Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 11
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by hostUniRule annotationSAAS annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1UniRule annotationSAAS annotation
Gene namesi
Name:L1UniRule annotationImported
OrganismiHuman papillomavirus type 11Imported
Taxonomic identifieri10580 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleusUniRule annotationSAAS annotation, T=7 icosahedral capsid proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi172Interchain (with Cys-424)UniRule annotation
Disulfide bondi424Interchain (with Cys-172)UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Keywords - Developmental stagei

Late proteinUniRule annotation

Structurei

3D structure databases

SMRiD7GM08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae L1 protein family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
HAMAPiMF_04002. PPV_L1. 1 hit.
InterProiView protein in InterPro
IPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
PfamiView protein in Pfam
PF00500. Late_protein_L1. 1 hit.
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

D7GM08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRPSDSTVY VPPPNPVSKV VATDAYVKRT NIFYHASSSR LLAVGHPYYS
60 70 80 90 100
IKKVNKTVVP KVSGYQYRVF KVVLPDPNKF ALPDSSLFDP TTQRLVWACT
110 120 130 140 150
GLEVGRGQPL GVGVSGHPLL NKYDDVENSG GYGGNPGQDN RVNVGMDYKQ
160 170 180 190 200
TQLCMVGCAP PLGEHWGKGT QCSNTSVQNG DCPPLELITS VIQDGDMVDT
210 220 230 240 250
GFGAMNFADL QTNKSDVPLD ICGTVCKYPD YLQMAADPYG DRLFFYLRKE
260 270 280 290 300
QMFARHFFNR AGTVGEPVPD DLLVKGGNNR SSVASSIYVH TPSGSLVSSE
310 320 330 340 350
AQLFNKPYWL QKAQGHNNGI CWGNHLFVTV VDTTRSTNMT LCASVSKSAT
360 370 380 390 400
YTNSDYKEYM RHVEEFDLQF IFQLCSITLS AEVMAYIHTM NPSVLEDWNF
410 420 430 440 450
GLSPPPNGTL EDTYRYVQSQ AITCQKPTPE KEKQDPYKDM SFWEVNLKEK
460 470 480 490 500
FSSELDQFPL GRKFLLQSGY RGRTSARTGI KRPAVSKPST APKRKRTKTK

K
Length:501
Mass (Da):55,835
Last modified:August 10, 2010 - v1
Checksum:i88957D023CC182A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU721794 Genomic DNA. Translation: AMN09992.1.
KU721795 Genomic DNA. Translation: AMN09993.1.
KU721796 Genomic DNA. Translation: AMN09994.1.
KU721797 Genomic DNA. Translation: AMN09995.1.
KU721798 Genomic DNA. Translation: AMN09996.1.
FN870688 Genomic DNA. Translation: CBM41705.1.
FN870690 Genomic DNA. Translation: CBM41707.1.
FN870691 Genomic DNA. Translation: CBM41708.1.
FN870693 Genomic DNA. Translation: CBM41710.1.
FN870695 Genomic DNA. Translation: CBM41712.1.
FN870697 Genomic DNA. Translation: CBM41714.1.
FN870698 Genomic DNA. Translation: CBM41715.1.
FN870699 Genomic DNA. Translation: CBM41716.1.
FN870701 Genomic DNA. Translation: CBM41718.1.
FN870702 Genomic DNA. Translation: CBM41719.1.
FN870703 Genomic DNA. Translation: CBM41720.1.
FN870705 Genomic DNA. Translation: CBM41722.1.
FN870706 Genomic DNA. Translation: CBM41723.1.
FN870707 Genomic DNA. Translation: CBM41724.1.
FN870708 Genomic DNA. Translation: CBM41725.1.
FN870709 Genomic DNA. Translation: CBM41726.1.
FN870710 Genomic DNA. Translation: CBM41727.1.
FN870712 Genomic DNA. Translation: CBM41729.1.
FN870713 Genomic DNA. Translation: CBM41730.1.
FN870714 Genomic DNA. Translation: CBM41731.1.
FN870715 Genomic DNA. Translation: CBM41732.1.
FN870716 Genomic DNA. Translation: CBM41733.1.
FN870718 Genomic DNA. Translation: CBM41735.1.
FN870719 Genomic DNA. Translation: CBM41736.1.
FN870720 Genomic DNA. Translation: CBM41737.1.
FN870721 Genomic DNA. Translation: CBM41738.1.
FN870722 Genomic DNA. Translation: CBM41739.1.
FN870723 Genomic DNA. Translation: CBM41740.1.
FN870724 Genomic DNA. Translation: CBM41741.1.
FN870726 Genomic DNA. Translation: CBM41743.1.
FN870727 Genomic DNA. Translation: CBM41744.1.
FN870728 Genomic DNA. Translation: CBM41745.1.
FN870729 Genomic DNA. Translation: CBM41746.1.
FN870731 Genomic DNA. Translation: CBM41748.1.
FN870732 Genomic DNA. Translation: CBM41749.1.
FN870733 Genomic DNA. Translation: CBM41750.1.
FN870734 Genomic DNA. Translation: CBM41751.1.
FN870735 Genomic DNA. Translation: CBM41752.1.
FN870736 Genomic DNA. Translation: CBM41753.1.
FN870737 Genomic DNA. Translation: CBM41754.1.
FN870738 Genomic DNA. Translation: CBM41755.1.
FN870739 Genomic DNA. Translation: CBM41756.1.
FN870740 Genomic DNA. Translation: CBM41757.1.
FN870741 Genomic DNA. Translation: CBM41758.1.
FN870742 Genomic DNA. Translation: CBM41759.1.
FN870743 Genomic DNA. Translation: CBM41760.1.
FN870744 Genomic DNA. Translation: CBM41761.1.
FN870745 Genomic DNA. Translation: CBM41762.1.
FN870746 Genomic DNA. Translation: CBM41763.1.
FN870747 Genomic DNA. Translation: CBM41764.1.
FN870748 Genomic DNA. Translation: CBM41765.1.
FN870749 Genomic DNA. Translation: CBM41766.1.
FN870750 Genomic DNA. Translation: CBM41767.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU721794 Genomic DNA. Translation: AMN09992.1.
KU721795 Genomic DNA. Translation: AMN09993.1.
KU721796 Genomic DNA. Translation: AMN09994.1.
KU721797 Genomic DNA. Translation: AMN09995.1.
KU721798 Genomic DNA. Translation: AMN09996.1.
FN870688 Genomic DNA. Translation: CBM41705.1.
FN870690 Genomic DNA. Translation: CBM41707.1.
FN870691 Genomic DNA. Translation: CBM41708.1.
FN870693 Genomic DNA. Translation: CBM41710.1.
FN870695 Genomic DNA. Translation: CBM41712.1.
FN870697 Genomic DNA. Translation: CBM41714.1.
FN870698 Genomic DNA. Translation: CBM41715.1.
FN870699 Genomic DNA. Translation: CBM41716.1.
FN870701 Genomic DNA. Translation: CBM41718.1.
FN870702 Genomic DNA. Translation: CBM41719.1.
FN870703 Genomic DNA. Translation: CBM41720.1.
FN870705 Genomic DNA. Translation: CBM41722.1.
FN870706 Genomic DNA. Translation: CBM41723.1.
FN870707 Genomic DNA. Translation: CBM41724.1.
FN870708 Genomic DNA. Translation: CBM41725.1.
FN870709 Genomic DNA. Translation: CBM41726.1.
FN870710 Genomic DNA. Translation: CBM41727.1.
FN870712 Genomic DNA. Translation: CBM41729.1.
FN870713 Genomic DNA. Translation: CBM41730.1.
FN870714 Genomic DNA. Translation: CBM41731.1.
FN870715 Genomic DNA. Translation: CBM41732.1.
FN870716 Genomic DNA. Translation: CBM41733.1.
FN870718 Genomic DNA. Translation: CBM41735.1.
FN870719 Genomic DNA. Translation: CBM41736.1.
FN870720 Genomic DNA. Translation: CBM41737.1.
FN870721 Genomic DNA. Translation: CBM41738.1.
FN870722 Genomic DNA. Translation: CBM41739.1.
FN870723 Genomic DNA. Translation: CBM41740.1.
FN870724 Genomic DNA. Translation: CBM41741.1.
FN870726 Genomic DNA. Translation: CBM41743.1.
FN870727 Genomic DNA. Translation: CBM41744.1.
FN870728 Genomic DNA. Translation: CBM41745.1.
FN870729 Genomic DNA. Translation: CBM41746.1.
FN870731 Genomic DNA. Translation: CBM41748.1.
FN870732 Genomic DNA. Translation: CBM41749.1.
FN870733 Genomic DNA. Translation: CBM41750.1.
FN870734 Genomic DNA. Translation: CBM41751.1.
FN870735 Genomic DNA. Translation: CBM41752.1.
FN870736 Genomic DNA. Translation: CBM41753.1.
FN870737 Genomic DNA. Translation: CBM41754.1.
FN870738 Genomic DNA. Translation: CBM41755.1.
FN870739 Genomic DNA. Translation: CBM41756.1.
FN870740 Genomic DNA. Translation: CBM41757.1.
FN870741 Genomic DNA. Translation: CBM41758.1.
FN870742 Genomic DNA. Translation: CBM41759.1.
FN870743 Genomic DNA. Translation: CBM41760.1.
FN870744 Genomic DNA. Translation: CBM41761.1.
FN870745 Genomic DNA. Translation: CBM41762.1.
FN870746 Genomic DNA. Translation: CBM41763.1.
FN870747 Genomic DNA. Translation: CBM41764.1.
FN870748 Genomic DNA. Translation: CBM41765.1.
FN870749 Genomic DNA. Translation: CBM41766.1.
FN870750 Genomic DNA. Translation: CBM41767.1.

3D structure databases

SMRiD7GM08.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
HAMAPiMF_04002. PPV_L1. 1 hit.
InterProiView protein in InterPro
IPR002210. Capsid_L1_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
PfamiView protein in Pfam
PF00500. Late_protein_L1. 1 hit.
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD7GM08_HPV11
AccessioniPrimary (citable) accession number: D7GM08
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 7, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.