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D7GI10 (D7GI10_PROFC) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). HAMAP-Rule MF_00252 SAAS SAAS002313

Cofactor

Binds 3 magnesium ions per subunit By similarity. HAMAP-Rule MF_00252

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00252 SAAS SAAS002313

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00252.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00252 RuleBase RU003746

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding4461Magnesium 1 By similarity HAMAP-Rule MF_00252
Metal binding4531Magnesium 1 By similarity HAMAP-Rule MF_00252
Metal binding4531Magnesium 2 By similarity HAMAP-Rule MF_00252

Sequences

Sequence LengthMass (Da)Tools
D7GI10 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 44C0D370AD7F77CF

FASTA53559,953
        10         20         30         40         50         60 
MSEQRPEKAP QSRGNQSAGK QSGGNQSRKN EPRKNGAADV EQDLPEQMRI RAEKRQRFLD 

        70         80         90        100        110        120 
EGKQAYPVDL RRDHTLAEVR ATWGHLAAGE ETQDEVTIGG RVIFIRNSGK LCFATLQDGF 

       130        140        150        160        170        180 
TPDQDAERLQ IMLSKAEVGD ESLAAWKADV DLGDFVWVRG RVIASKRGEL SVMASEWKLA 

       190        200        210        220        230        240 
SKALRPLPTL HNDLSEEARV RQRYNDLIVR PAARTMVRQR ALITRKIRET LEEQGYLEVE 

       250        260        270        280        290        300 
TPVLQSVHGG AAARPFTTHL NAFDIDMYLR IALELHLKRV MVGGADRVYE MGRVFRNEGV 

       310        320        330        340        350        360 
DSSHSPEFTM LEAYQSWGDQ FTIAETLKSI IMKVAEALDI FEIPTDQGVI DLKGEWIWLP 

       370        380        390        400        410        420 
VYEGLSGEVG EEITTKTPVE HLRHIADAHK VDYDASWIDQ KMVLHLFEEL VEKGLTQPTF 

       430        440        450        460        470        480 
VCDFPEIAQP LARRHRSKPG CIEAWDLIIG GMERGTGFSE LIDPVIQREI LTQQSLAAAA 

       490        500        510        520        530 
GDPEAMQLDE DFLNALEQGC PPMGGLGLGV DRLVMLFTGA GIRETILFPL LRPLN

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References

[1]"The complete genome of Propionibacterium freudenreichii CIRM-BIA1, a hardy actinobacterium with food and probiotic applications."
Falentin H., Deutsch S.M., Jan G., Loux V., Thierry A., Parayre S., Maillard M.B., Dherbecourt J., Cousin F.J., Jardin J., Siguier P., Couloux A., Barbe V., Vacherie B., Wincker P., Gibrat J.F., Gaillardin C., Lortal S.
PLoS ONE 5:E11748-E11748(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9614 / CIP 103027 / CIRM-BIA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN806773 Genomic DNA. Translation: CBL55732.1.
RefSeqYP_003687181.1. NC_014215.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBL55732; CBL55732; PFREUD_02170.
GeneID9282142.
KEGGpfr:PFREUD_02170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000236578.
KOK04567.

Enzyme and pathway databases

BioCycPFRE754252:GI1A-236-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00252. Lys_tRNA_synth_class2.
InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
PANTHERPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF4. PTHR22594:SF4. 1 hit.
PfamPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR00982. TRNASYNTHLYS.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00499. lysS_bact. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7GI10_PROFC
AccessionPrimary (citable) accession number: D7GI10
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 29, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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