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Protein

Transketolase

Gene

tktA

Organism
Helicobacter pylori (strain B8)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
LigandCalciumUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
TransketolaseUniRule annotation (EC:2.2.1.1UniRule annotation)
Gene namesi
Name:tktAImported
Ordered Locus Names:HPB8_1207Imported
OrganismiHelicobacter pylori (strain B8)Imported
Taxonomic identifieri693745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000007091 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei407 – 428HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 39TRANSKETOLASE_1InterPro annotationAdd BLAST21

Sequence similaritiesi

Belongs to the transketolase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000225954
KOiK00615
OMAiFADYMRG
OrthoDBiPOG091H02B4

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR005478 Transketolase_bac-like
IPR020826 Transketolase_BS
IPR033248 Transketolase_C
IPR033247 Transketolase_fam
IPR005474 Transketolase_N
PANTHERiPTHR43522 PTHR43522, 1 hit
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
PF00456 Transketolase_N, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00232 tktlase_bact, 1 hit
PROSITEiView protein in PROSITE
PS00801 TRANSKETOLASE_1, 1 hit
PS00802 TRANSKETOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

D7FF07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSNADLER LKSMANTLRF LCADMIDKAN SGHPGVCLGL ADVMVVLSLH
60 70 80 90 100
LNLNPINPKW LNRDRLVFSG GHASALAYSL LHLWGFDLSL EDLKHFRQLH
110 120 130 140 150
SKTPGHPELH HTEGIEITTG PLGQGFANAV GFSMASQYAQ NLLDKEVISH
160 170 180 190 200
KVYCLCGDGD LQEGISYESA SLAGHLRLDN LIVIYDSNQI SIEGAINISF
210 220 230 240 250
SEQVKTRFLA QNWEVLECDG HDYQAIHNAL EEAKKSHKPT LLIAHTIIGK
260 270 280 290 300
GAVGLEGSEK THGSPLNKEV LKQSKENAQI NPDESFIISP KNKMHFEEVK
310 320 330 340 350
VRGASLEALW EKSLSPKTKE KIHALKDFDF STIHYPTFKK GESLATRVSN
360 370 380 390 400
GMILNAIAKE CEGFLGGSAD LAPSNNTQLK HSGDFPLGQN LHFGIREHAM
410 420 430 440 450
GAITNALAAY GLFLPFCATF FVFSDYLMPS MRLSALMKLK ALFIFTHDSI
460 470 480 490 500
GVGEDGATHQ PIEQLSHLRA LPNFYAFRPS DAFENKACMQ VALSLNAPSG
510 520 530 540 550
LILSRQNLPV LDEVSKERVL KGAYVKYDAK DPIITLVASG SEISLALESA
560 570 580 590 600
KMLERENIPT QVVSAPCFDL LIEQDESYLK ELFKGKVLVI EASRAIEWYR
610 620 630 640
FADKIIGMDS FGSSAKGDKL FEKFGFSVEN ITAQAKRLLN A
Length:641
Mass (Da):70,670
Last modified:August 10, 2010 - v1
Checksum:i8C9B8386101E00B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN598874 Genomic DNA Translation: CBI66764.1
RefSeqiWP_001239844.1, NC_014256.1

Genome annotation databases

EnsemblBacteriaiCBI66764; CBI66764; HPB8_1207
KEGGihpl:HPB8_1207

Similar proteinsi

Entry informationi

Entry nameiD7FF07_HELP3
AccessioniPrimary (citable) accession number: D7FF07
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health