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D7FF07

- D7FF07_HELP3

UniProt

D7FF07 - D7FF07_HELP3

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Protein
Transketolase
Gene
tktA, HPB8_1207
Organism
Helicobacter pylori (strain B8)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate By similarity.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+ By similarity.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transketolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationsImported

    Keywords - Ligandi

    CalciumUniRule annotation, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Thiamine pyrophosphateUniRule annotationSAAS annotations

    Enzyme and pathway databases

    BioCyciHPYL693745:GJAE-1228-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TransketolaseUniRule annotation (EC:2.2.1.1UniRule annotation)
    Gene namesi
    Name:tktAImported
    Ordered Locus Names:HPB8_1207Imported
    OrganismiHelicobacter pylori (strain B8)Imported
    Taxonomic identifieri693745 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000007091: Chromosome

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transketolase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000225954.
    KOiK00615.
    OMAiPMGMAPI.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005478. Transketolase_bac-like.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    PF00456. Transketolase_N. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00232. tktlase_bact. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7FF07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSNADLER LKSMANTLRF LCADMIDKAN SGHPGVCLGL ADVMVVLSLH    50
    LNLNPINPKW LNRDRLVFSG GHASALAYSL LHLWGFDLSL EDLKHFRQLH 100
    SKTPGHPELH HTEGIEITTG PLGQGFANAV GFSMASQYAQ NLLDKEVISH 150
    KVYCLCGDGD LQEGISYESA SLAGHLRLDN LIVIYDSNQI SIEGAINISF 200
    SEQVKTRFLA QNWEVLECDG HDYQAIHNAL EEAKKSHKPT LLIAHTIIGK 250
    GAVGLEGSEK THGSPLNKEV LKQSKENAQI NPDESFIISP KNKMHFEEVK 300
    VRGASLEALW EKSLSPKTKE KIHALKDFDF STIHYPTFKK GESLATRVSN 350
    GMILNAIAKE CEGFLGGSAD LAPSNNTQLK HSGDFPLGQN LHFGIREHAM 400
    GAITNALAAY GLFLPFCATF FVFSDYLMPS MRLSALMKLK ALFIFTHDSI 450
    GVGEDGATHQ PIEQLSHLRA LPNFYAFRPS DAFENKACMQ VALSLNAPSG 500
    LILSRQNLPV LDEVSKERVL KGAYVKYDAK DPIITLVASG SEISLALESA 550
    KMLERENIPT QVVSAPCFDL LIEQDESYLK ELFKGKVLVI EASRAIEWYR 600
    FADKIIGMDS FGSSAKGDKL FEKFGFSVEN ITAQAKRLLN A 641
    Length:641
    Mass (Da):70,670
    Last modified:August 10, 2010 - v1
    Checksum:i8C9B8386101E00B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN598874 Genomic DNA. Translation: CBI66764.1.
    RefSeqiYP_003729228.1. NC_014256.1.

    Genome annotation databases

    EnsemblBacteriaiCBI66764; CBI66764; HPB8_1207.
    GeneIDi9350183.
    KEGGihpl:HPB8_1207.
    PATRICi38176717. VBIHelPyl164240_1163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN598874 Genomic DNA. Translation: CBI66764.1 .
    RefSeqi YP_003729228.1. NC_014256.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBI66764 ; CBI66764 ; HPB8_1207 .
    GeneIDi 9350183.
    KEGGi hpl:HPB8_1207.
    PATRICi 38176717. VBIHelPyl164240_1163.

    Phylogenomic databases

    HOGENOMi HOG000225954.
    KOi K00615.
    OMAi PMGMAPI.

    Enzyme and pathway databases

    BioCyci HPYL693745:GJAE-1228-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR005478. Transketolase_bac-like.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    PF00456. Transketolase_N. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00232. tktlase_bact. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8."
      Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A., Kurtz S., Rieder G.
      BMC Genomics 11:335-335(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B8Imported.

    Entry informationi

    Entry nameiD7FF07_HELP3
    AccessioniPrimary (citable) accession number: D7FF07
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: June 11, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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