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Protein

Transketolase

Gene

tktA

Organism
Helicobacter pylori (strain B8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Ca2+UniRule annotation, Mn2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co2+.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Ligandi

CalciumUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL693745:GJAE-1228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TransketolaseUniRule annotationImported (EC:2.2.1.1UniRule annotationImported)
Gene namesi
Name:tktAImported
Ordered Locus Names:HPB8_1207Imported
OrganismiHelicobacter pylori (strain B8)Imported
Taxonomic identifieri693745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007091 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the transketolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225954.
KOiK00615.
OMAiDFEVPQE.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00232. tktlase_bact. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7FF07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSNADLER LKSMANTLRF LCADMIDKAN SGHPGVCLGL ADVMVVLSLH
60 70 80 90 100
LNLNPINPKW LNRDRLVFSG GHASALAYSL LHLWGFDLSL EDLKHFRQLH
110 120 130 140 150
SKTPGHPELH HTEGIEITTG PLGQGFANAV GFSMASQYAQ NLLDKEVISH
160 170 180 190 200
KVYCLCGDGD LQEGISYESA SLAGHLRLDN LIVIYDSNQI SIEGAINISF
210 220 230 240 250
SEQVKTRFLA QNWEVLECDG HDYQAIHNAL EEAKKSHKPT LLIAHTIIGK
260 270 280 290 300
GAVGLEGSEK THGSPLNKEV LKQSKENAQI NPDESFIISP KNKMHFEEVK
310 320 330 340 350
VRGASLEALW EKSLSPKTKE KIHALKDFDF STIHYPTFKK GESLATRVSN
360 370 380 390 400
GMILNAIAKE CEGFLGGSAD LAPSNNTQLK HSGDFPLGQN LHFGIREHAM
410 420 430 440 450
GAITNALAAY GLFLPFCATF FVFSDYLMPS MRLSALMKLK ALFIFTHDSI
460 470 480 490 500
GVGEDGATHQ PIEQLSHLRA LPNFYAFRPS DAFENKACMQ VALSLNAPSG
510 520 530 540 550
LILSRQNLPV LDEVSKERVL KGAYVKYDAK DPIITLVASG SEISLALESA
560 570 580 590 600
KMLERENIPT QVVSAPCFDL LIEQDESYLK ELFKGKVLVI EASRAIEWYR
610 620 630 640
FADKIIGMDS FGSSAKGDKL FEKFGFSVEN ITAQAKRLLN A
Length:641
Mass (Da):70,670
Last modified:August 10, 2010 - v1
Checksum:i8C9B8386101E00B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN598874 Genomic DNA. Translation: CBI66764.1.
RefSeqiWP_001239844.1. NC_014256.1.

Genome annotation databases

EnsemblBacteriaiCBI66764; CBI66764; HPB8_1207.
KEGGihpl:HPB8_1207.
PATRICi38176717. VBIHelPyl164240_1163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN598874 Genomic DNA. Translation: CBI66764.1.
RefSeqiWP_001239844.1. NC_014256.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBI66764; CBI66764; HPB8_1207.
KEGGihpl:HPB8_1207.
PATRICi38176717. VBIHelPyl164240_1163.

Phylogenomic databases

HOGENOMiHOG000225954.
KOiK00615.
OMAiDFEVPQE.

Enzyme and pathway databases

BioCyciHPYL693745:GJAE-1228-MONOMER.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00232. tktlase_bact. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8."
    Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A., Kurtz S., Rieder G.
    BMC Genomics 11:335-335(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B8Imported.

Entry informationi

Entry nameiD7FF07_HELP3
AccessioniPrimary (citable) accession number: D7FF07
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: July 22, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.