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D7FF07

- D7FF07_HELP3

UniProt

D7FF07 - D7FF07_HELP3

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Protein

Transketolase

Gene

tktA

Organism
Helicobacter pylori (strain B8)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).UniRule annotation
  • Note: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transketolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Ligandi

CalciumUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL693745:GJAE-1228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TransketolaseUniRule annotation (EC:2.2.1.1UniRule annotation)
Gene namesi
Name:tktAImported
Ordered Locus Names:HPB8_1207Imported
OrganismiHelicobacter pylori (strain B8)Imported
Taxonomic identifieri693745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007091: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the transketolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225954.
KOiK00615.
OMAiPMGMAPI.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00232. tktlase_bact. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7FF07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSNADLER LKSMANTLRF LCADMIDKAN SGHPGVCLGL ADVMVVLSLH
60 70 80 90 100
LNLNPINPKW LNRDRLVFSG GHASALAYSL LHLWGFDLSL EDLKHFRQLH
110 120 130 140 150
SKTPGHPELH HTEGIEITTG PLGQGFANAV GFSMASQYAQ NLLDKEVISH
160 170 180 190 200
KVYCLCGDGD LQEGISYESA SLAGHLRLDN LIVIYDSNQI SIEGAINISF
210 220 230 240 250
SEQVKTRFLA QNWEVLECDG HDYQAIHNAL EEAKKSHKPT LLIAHTIIGK
260 270 280 290 300
GAVGLEGSEK THGSPLNKEV LKQSKENAQI NPDESFIISP KNKMHFEEVK
310 320 330 340 350
VRGASLEALW EKSLSPKTKE KIHALKDFDF STIHYPTFKK GESLATRVSN
360 370 380 390 400
GMILNAIAKE CEGFLGGSAD LAPSNNTQLK HSGDFPLGQN LHFGIREHAM
410 420 430 440 450
GAITNALAAY GLFLPFCATF FVFSDYLMPS MRLSALMKLK ALFIFTHDSI
460 470 480 490 500
GVGEDGATHQ PIEQLSHLRA LPNFYAFRPS DAFENKACMQ VALSLNAPSG
510 520 530 540 550
LILSRQNLPV LDEVSKERVL KGAYVKYDAK DPIITLVASG SEISLALESA
560 570 580 590 600
KMLERENIPT QVVSAPCFDL LIEQDESYLK ELFKGKVLVI EASRAIEWYR
610 620 630 640
FADKIIGMDS FGSSAKGDKL FEKFGFSVEN ITAQAKRLLN A
Length:641
Mass (Da):70,670
Last modified:August 10, 2010 - v1
Checksum:i8C9B8386101E00B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN598874 Genomic DNA. Translation: CBI66764.1.
RefSeqiWP_001239844.1. NC_014256.1.
YP_003729228.1. NC_014256.1.

Genome annotation databases

EnsemblBacteriaiCBI66764; CBI66764; HPB8_1207.
GeneIDi9350183.
KEGGihpl:HPB8_1207.
PATRICi38176717. VBIHelPyl164240_1163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN598874 Genomic DNA. Translation: CBI66764.1 .
RefSeqi WP_001239844.1. NC_014256.1.
YP_003729228.1. NC_014256.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBI66764 ; CBI66764 ; HPB8_1207 .
GeneIDi 9350183.
KEGGi hpl:HPB8_1207.
PATRICi 38176717. VBIHelPyl164240_1163.

Phylogenomic databases

HOGENOMi HOG000225954.
KOi K00615.
OMAi PMGMAPI.

Enzyme and pathway databases

BioCyci HPYL693745:GJAE-1228-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00232. tktlase_bact. 1 hit.
PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8."
    Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A., Kurtz S., Rieder G.
    BMC Genomics 11:335-335(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B8Imported.

Entry informationi

Entry nameiD7FF07_HELP3
AccessioniPrimary (citable) accession number: D7FF07
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3