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D7FDA7

- D7FDA7_HELP3

UniProt

D7FDA7 - D7FDA7_HELP3

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Protein

Alanine racemase

Gene

alr

Organism
Helicobacter pylori (strain B8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL693745:GJAE-627-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HPB8_607Imported
OrganismiHelicobacter pylori (strain B8)Imported
Taxonomic identifieri693745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007091: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD7FDA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7FDA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKRASFVEV DTASLRHNFS AVKSIVPKDA HIMAVVKANA YGAGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSHFPKTPI LILGYSPNAN ASMLIDNDLS
110 120 130 140 150
AMVFSLEQAE VFSQMALKAK KRLKIHLKID TGMHRLGLEP NFKSIEIIKK
160 170 180 190 200
IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLNQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNEMK ESCPTILKNV
260 270 280 290 300
ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLARALGN
310 320 330 340 350
RIQVVINNQL APLIGKVCMD QCFVKLNDIQ AKEGDEVILF GDKSAKANDA
360 370
SEIATLLNTI AYETISTLSK RLERVYI
Length:377
Mass (Da):41,813
Last modified:August 10, 2010 - v1
Checksum:i21ECC6397F1026A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN598874 Genomic DNA. Translation: CBI66164.1.
RefSeqiWP_000917920.1. NC_014256.1.
YP_003728628.1. NC_014256.1.

Genome annotation databases

EnsemblBacteriaiCBI66164; CBI66164; HPB8_607.
GeneIDi9349645.
KEGGihpl:HPB8_607.
PATRICi38175551. VBIHelPyl164240_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN598874 Genomic DNA. Translation: CBI66164.1 .
RefSeqi WP_000917920.1. NC_014256.1.
YP_003728628.1. NC_014256.1.

3D structure databases

ProteinModelPortali D7FDA7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBI66164 ; CBI66164 ; HPB8_607 .
GeneIDi 9349645.
KEGGi hpl:HPB8_607.
PATRICi 38175551. VBIHelPyl164240_0586.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL693745:GJAE-627-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8."
    Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A., Kurtz S., Rieder G.
    BMC Genomics 11:335-335(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B8Imported.

Entry informationi

Entry nameiD7FDA7_HELP3
AccessioniPrimary (citable) accession number: D7FDA7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3