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D7FDA7

- D7FDA7_HELP3

UniProt

D7FDA7 - D7FDA7_HELP3

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Protein

Alanine racemase

Gene
alr, HPB8_607
Organism
Helicobacter pylori (strain B8)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei135 – 1351Substrate By similarityUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciHPYL693745:GJAE-627-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HPB8_607Imported
OrganismiHelicobacter pylori (strain B8)Imported
Taxonomic identifieri693745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007091: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD7FDA7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7FDA7-1 [UniParc]FASTAAdd to Basket

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MLKRASFVEV DTASLRHNFS AVKSIVPKDA HIMAVVKANA YGAGAIKASE    50
IFLQEGANYL GVATLDEALE LRSHFPKTPI LILGYSPNAN ASMLIDNDLS 100
AMVFSLEQAE VFSQMALKAK KRLKIHLKID TGMHRLGLEP NFKSIEIIKK 150
IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLNQKIEFQY 200
RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNEMK ESCPTILKNV 250
ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLARALGN 300
RIQVVINNQL APLIGKVCMD QCFVKLNDIQ AKEGDEVILF GDKSAKANDA 350
SEIATLLNTI AYETISTLSK RLERVYI 377
Length:377
Mass (Da):41,813
Last modified:August 10, 2010 - v1
Checksum:i21ECC6397F1026A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN598874 Genomic DNA. Translation: CBI66164.1.
RefSeqiWP_000917920.1. NC_014256.1.
YP_003728628.1. NC_014256.1.

Genome annotation databases

EnsemblBacteriaiCBI66164; CBI66164; HPB8_607.
GeneIDi9349645.
KEGGihpl:HPB8_607.
PATRICi38175551. VBIHelPyl164240_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN598874 Genomic DNA. Translation: CBI66164.1 .
RefSeqi WP_000917920.1. NC_014256.1.
YP_003728628.1. NC_014256.1.

3D structure databases

ProteinModelPortali D7FDA7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBI66164 ; CBI66164 ; HPB8_607 .
GeneIDi 9349645.
KEGGi hpl:HPB8_607.
PATRICi 38175551. VBIHelPyl164240_0586.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HPYL693745:GJAE-627-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8."
    Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A., Kurtz S., Rieder G.
    BMC Genomics 11:335-335(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B8Imported.

Entry informationi

Entry nameiD7FDA7_HELP3
AccessioniPrimary (citable) accession number: D7FDA7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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