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D7FDA7 (D7FDA7_HELP3) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site371Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2711Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1351Substrate By similarity HAMAP-Rule MF_01201
Binding site3191Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue371N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
D7FDA7 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 21ECC6397F1026A2

FASTA37741,813
        10         20         30         40         50         60 
MLKRASFVEV DTASLRHNFS AVKSIVPKDA HIMAVVKANA YGAGAIKASE IFLQEGANYL 

        70         80         90        100        110        120 
GVATLDEALE LRSHFPKTPI LILGYSPNAN ASMLIDNDLS AMVFSLEQAE VFSQMALKAK 

       130        140        150        160        170        180 
KRLKIHLKID TGMHRLGLEP NFKSIEIIKK IRALKGLEVE GIFTHLSNAD AKIKTHAKNQ 

       190        200        210        220        230        240 
MKAFNAFLEQ LLNQKIEFQY RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNEMK 

       250        260        270        280        290        300 
ESCPTILKNV ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLARALGN 

       310        320        330        340        350        360 
RIQVVINNQL APLIGKVCMD QCFVKLNDIQ AKEGDEVILF GDKSAKANDA SEIATLLNTI 

       370 
AYETISTLSK RLERVYI 

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References

[1]"Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8."
Farnbacher M., Jahns T., Willrodt D., Daniel R., Haas R., Goesmann A., Kurtz S., Rieder G.
BMC Genomics 11:335-335(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B8 EMBL CBI66164.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN598874 Genomic DNA. Translation: CBI66164.1.
RefSeqYP_003728628.1. NC_014256.1.

3D structure databases

ProteinModelPortalD7FDA7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBI66164; CBI66164; HPB8_607.
GeneID9349645.
KEGGhpl:HPB8_607.
PATRIC38175551. VBIHelPyl164240_0586.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.
OMALWQLEAI.

Enzyme and pathway databases

BioCycHPYL693745:GJAE-627-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7FDA7_HELP3
AccessionPrimary (citable) accession number: D7FDA7
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)