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D7E9E7

- HPRT_METEZ

UniProt

D7E9E7 - HPRT_METEZ

Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanohalobium evestigatum (strain DSM 3721 / OCM 161 / Z-7303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciMEVE644295:GHG3-1390-MONOMER.
    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
    Short name:
    HGPRTaseUniRule annotation
    Gene namesi
    Name:hptUniRule annotation
    Ordered Locus Names:Metev_1361
    OrganismiMethanohalobium evestigatum (strain DSM 3721 / OCM 161 / Z-7303)
    Taxonomic identifieri644295 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanohalobium
    ProteomesiUP000000391: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415475Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD7E9E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228520.
    KOiK00759.
    OMAiIATDIPY.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01467. Hypx_phosphoribosyltr.
    InterProiIPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7E9E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDTLQKSLE ISPVIKKNNY YYFINPITDG IPSVEPELLQ EIANHIVENT    50
    KMNVDKIVSI EAMGIPIATS LSLKSGVPLS IIRKRKYGLN GEIAVSQSTG 100
    YSKGQLYING IESGDRILIV DDVVSTGGTL QSVIKALIDA GSIIDEVVVI 150
    VERGEGVSKL KEMNIPVKSL IKINVDEKGV SIREVNGGKQ 190
    Length:190
    Mass (Da):20,592
    Last modified:August 10, 2010 - v1
    Checksum:iFC776A9445A2FD81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002069 Genomic DNA. Translation: ADI74219.1.
    RefSeqiYP_003727015.1. NC_014253.1.

    Genome annotation databases

    EnsemblBacteriaiADI74219; ADI74219; Metev_1361.
    GeneIDi9346996.
    KEGGimev:Metev_1361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002069 Genomic DNA. Translation: ADI74219.1 .
    RefSeqi YP_003727015.1. NC_014253.1.

    3D structure databases

    ProteinModelPortali D7E9E7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI74219 ; ADI74219 ; Metev_1361 .
    GeneIDi 9346996.
    KEGGi mev:Metev_1361.

    Phylogenomic databases

    HOGENOMi HOG000228520.
    KOi K00759.
    OMAi IATDIPY.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .
    BioCyci MEVE644295:GHG3-1390-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01467. Hypx_phosphoribosyltr.
    InterProi IPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence chromosome of Methanohalobium evestigatum Z-7303."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Anderson I., Woyke T.
      Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 3721 / OCM 161 / Z-7303.

    Entry informationi

    Entry nameiHPRT_METEZ
    AccessioniPrimary (citable) accession number: D7E9E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3