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D7E5F3 (D7E5F3_NOSA0) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CTP synthase HAMAP-Rule MF_01227
EC=6.3.4.2 HAMAP-Rule MF_01227
Alternative name(s):
CTP synthetase HAMAP-Rule MF_01227
UTP--ammonia ligase HAMAP-Rule MF_01227
Gene names
Name:pyrG HAMAP-Rule MF_01227
Ordered Locus Names:Aazo_4054 EMBL ADI65513.1
OrganismNostoc azollae (strain 0708) (Anabaena azollae (strain 0708)) [Complete proteome] [HAMAP] EMBL ADI65513.1
Taxonomic identifier551115 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Nostocales › Nostocaceae › Trichormus ›

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP-Rule MF_01227 SAAS SAAS004468

Catalytic activity

ATP + UTP + NH3 = ADP + phosphate + CTP. HAMAP-Rule MF_01227 SAAS SAAS004468

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP-Rule MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP-Rule MF_01227 SAAS SAAS004468

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01227

Sequence similarities

Belongs to the CTP synthase family. HAMAP-Rule MF_01227

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01227 SAAS SAAS004468

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain292 – 534243Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01227
Region1 – 254254Aminator domain By similarity HAMAP-Rule MF_01227

Sites

Active site3811Nucleophile By similarity HAMAP-Rule MF_01227
Active site5071 By similarity HAMAP-Rule MF_01227
Active site5091 By similarity HAMAP-Rule MF_01227

Sequences

Sequence LengthMass (Da)Tools
D7E5F3 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 011A412777F00F30

FASTA54560,914
        10         20         30         40         50         60 
MTKFIFVTGG VVSSIGKGIV AASLGRLLKS RDYSVSILKL DPYINVDPGT MSPFQHGEVF 

        70         80         90        100        110        120 
VTQDGAETDL DLGHYERFTD TSMSRLNSVT TGLIYQSVIN KERRGDYNGG TVQVIPHITN 

       130        140        150        160        170        180 
EIKDRILRVA KETNPSTVIT EIGGTVGDIE SLPFLEAIRQ LRKEVGRQNV LYMHVTLLPW 

       190        200        210        220        230        240 
IASAGEMKTK PTQHSVKELR SIGIQPDILV CRCDRTIPVG LKQKLSEFCD VPVECVITCQ 

       250        260        270        280        290        300 
DASSIYEVPL ILEREGLAQQ TLDLLQMEQG QPNLTQWEIM VERMYSPKYS VEIAIVGKYV 

       310        320        330        340        350        360 
RLSDAYLSVV ESLRHAAIAT HSDLRLRWVN SEALENEPAE NYLAGVDGII VPGGFGSRGI 

       370        380        390        400        410        420 
DGKIAAIKYA RDRQIPFLGL CLGMQCSVIE WARNVEGLID ANSAEFDPYT NDPVINLLPE 

       430        440        450        460        470        480 
QQDVVDLGGT MRLGLYPCRI QPGTRAFELY QQEVIYERHR HRYEFNNLYR NTLLDSGYVV 

       490        500        510        520        530        540 
SGTSPDGRLV EIVEYPKHPF FIACQFHPEF RSRPSNPHPL FKGFMEAAIP LTQPTPTAPK 


PVQVS

« Hide

References

[1]"Genome erosion in a nitrogen-fixing vertically transmitted endosymbiotic multicellular cyanobacterium."
Ran L., Larsson J., Vigil-Stenman T., Nylander J.A., Ininbergs K., Zheng W.W., Lapidus A., Lowry S., Haselkorn R., Bergman B.
PLoS ONE 5:E11486-E11486(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 0708 EMBL ADI65513.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002059 Genomic DNA. Translation: ADI65513.1.
RefSeqYP_003722636.1. NC_014248.1.

3D structure databases

ProteinModelPortalD7E5F3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI65513; ADI65513; Aazo_4054.
GeneID9341859.
KEGGnaz:Aazo_4054.
PATRIC38231894. VBINosAzo102301_5255.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000077515.
KOK01937.
OMATNEIKDR.

Enzyme and pathway databases

UniPathwayUPA00159; UER00277.

Family and domain databases

HAMAPMF_01227. PyrG.
InterProIPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE_1.
[Graphical view]
PANTHERPTHR11550. PTHR11550. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7E5F3_NOSA0
AccessionPrimary (citable) accession number: D7E5F3
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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