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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Nostoc azollae (strain 0708) (Anabaena azollae (strain 0708))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi296Magnesium or manganese 1UniRule annotation1
Metal bindingi310Magnesium or manganese 1UniRule annotation1
Metal bindingi310Magnesium or manganese 2UniRule annotation1
Metal bindingi312Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Aazo_0272Imported
OrganismiNostoc azollae (strain 0708) (Anabaena azollae (strain 0708))Imported
Taxonomic identifieri551115 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000001511 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi551115.Aazo_0272.

Structurei

3D structure databases

ProteinModelPortaliD7DYP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 343ATP-graspInterPro annotationAdd BLAST210

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011593.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D7DYP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLRVGLLF GGRSGEHEVS IISARGIANA LSAEENSHKY EIMPFYIQKD
60 70 80 90 100
GFWQAGEVAQ QVLTSGVAKE HPGNRANLWQ FPPQTAEIDL WFPILHGPNG
110 120 130 140 150
EDGTIQALLT LMQVPFVGSG VLGSATGMDK IAMKTAFAQA GLPQVKYKAL
160 170 180 190 200
TRAQIWSNPC VFPKLCDEIE ATLGYPYFVK PANLGSSVGI AKVQSRQELE
210 220 230 240 250
AALDNAATYD RRIIVEAGVV AREVECAVLG NDNPKASVIG EITFDSDFYD
260 270 280 290 300
YETKYTQGKA DLFIPAHLPE SAVQQIQEKA LQAFTAVDAA GLARVDFFYV
310 320 330 340 350
EATGEILINE INTLPGFTST SMYPQLWANT GISFPKLVDQ LIQLAMERHS

N
Length:351
Mass (Da):38,306
Last modified:August 10, 2010 - v1
Checksum:i3946D7BA9DC96E23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002059 Genomic DNA. Translation: ADI62865.1.
RefSeqiWP_013189885.1. NC_014248.1.

Genome annotation databases

EnsemblBacteriaiADI62865; ADI62865; Aazo_0272.
KEGGinaz:Aazo_0272.

Similar proteinsi

Entry informationi

Entry nameiD7DYP2_NOSA0
AccessioniPrimary (citable) accession number: D7DYP2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 27, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported