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D7DYP2 (D7DYP2_NOSA0) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Aazo_0272 EMBL ADI62865.1
OrganismNostoc azollae (strain 0708) (Anabaena azollae (strain 0708)) [Complete proteome] [HAMAP] EMBL ADI62865.1
Taxonomic identifier551115 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain134 – 343210ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding170 – 22556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2961Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3101Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3101Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D7DYP2 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 3946D7BA9DC96E23

FASTA35138,306
        10         20         30         40         50         60 
MSKLRVGLLF GGRSGEHEVS IISARGIANA LSAEENSHKY EIMPFYIQKD GFWQAGEVAQ 

        70         80         90        100        110        120 
QVLTSGVAKE HPGNRANLWQ FPPQTAEIDL WFPILHGPNG EDGTIQALLT LMQVPFVGSG 

       130        140        150        160        170        180 
VLGSATGMDK IAMKTAFAQA GLPQVKYKAL TRAQIWSNPC VFPKLCDEIE ATLGYPYFVK 

       190        200        210        220        230        240 
PANLGSSVGI AKVQSRQELE AALDNAATYD RRIIVEAGVV AREVECAVLG NDNPKASVIG 

       250        260        270        280        290        300 
EITFDSDFYD YETKYTQGKA DLFIPAHLPE SAVQQIQEKA LQAFTAVDAA GLARVDFFYV 

       310        320        330        340        350 
EATGEILINE INTLPGFTST SMYPQLWANT GISFPKLVDQ LIQLAMERHS N 

« Hide

References

[1]"Genome erosion in a nitrogen-fixing vertically transmitted endosymbiotic multicellular cyanobacterium."
Ran L., Larsson J., Vigil-Stenman T., Nylander J.A., Ininbergs K., Zheng W.W., Lapidus A., Lowry S., Haselkorn R., Bergman B.
PLoS ONE 5:E11486-E11486(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 0708 EMBL ADI62865.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002059 Genomic DNA. Translation: ADI62865.1.
RefSeqYP_003719988.1. NC_014248.1.

3D structure databases

ProteinModelPortalD7DYP2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI62865; ADI62865; Aazo_0272.
GeneID9338056.
KEGGnaz:Aazo_0272.
PATRIC38222109. VBINosAzo102301_0369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMARSAYGIY.

Enzyme and pathway databases

BioCycTAZO551115:GH0O-272-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7DYP2_NOSA0
AccessionPrimary (citable) accession number: D7DYP2
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)