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D7DGR8

- D7DGR8_CHLTL

UniProt

D7DGR8 - D7DGR8_CHLTL

Protein

Elongation factor Tu

Gene

tuf

Organism
Chlamydia trachomatis serovar D (strain D-LC)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPUniRule annotation
    Nucleotide bindingi86 – 905GTPUniRule annotation
    Nucleotide bindingi141 – 1444GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTRA759364:GLAV-331-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotationImported
    Ordered Locus Names:CTDLC_0322Imported
    OrganismiChlamydia trachomatis serovar D (strain D-LC)Imported
    Taxonomic identifieri759364 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000382: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD7DGR8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.UniRule annotation
    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiGTEMCMP.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7DGR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIFEMSKET FQRNKPHINI GTIGHVDHGK TTLTAAITRA LSGDGLADFR    50
    DYSSIDNTPE EKARGITINA SHVEYETANR HYAHVDCPGH ADYVKNMITG 100
    AAQMDGAILV VSATDGAMPQ TKEHILLARQ VGVPYIVVFL NKIDMISEED 150
    AELVDLVEME LVELLEEKGY KGCPIIRGSA LKALEGDAAY IEKVRELMQA 200
    VDDNIPTPER EIDKPFLMPI EDVFSISGRG TVVTGRIERG IVKVSDKVQL 250
    VGLRDTKETI VTGVEMFRKE LPEGRAGENV GLLLRGIGKN DVERGMVVCL 300
    PNSVKPHTQF KCAVYVLQKE EGGRHKPFFT GYRPQFFFRT TDVTGVVTLP 350
    EGIEMVMPGD NVEFEVQLIS PVALEEGMRF AIREGGRTIG AGTISKIIA 399
    Length:399
    Mass (Da):43,969
    Last modified:August 10, 2010 - v1
    Checksum:iB507303F29FB2A98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002054 Genomic DNA. Translation: ADI52009.1.
    RefSeqiWP_014541402.1. NC_017436.1.
    YP_005812252.1. NC_017436.1.

    Genome annotation databases

    EnsemblBacteriaiADI52009; ADI52009; CTDLC_0322.
    GeneIDi12387806.
    KEGGictf:CTDLC_0322.
    PATRICi42818551. VBIChlTra159408_0346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002054 Genomic DNA. Translation: ADI52009.1 .
    RefSeqi WP_014541402.1. NC_017436.1.
    YP_005812252.1. NC_017436.1.

    3D structure databases

    ProteinModelPortali D7DGR8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI52009 ; ADI52009 ; CTDLC_0322 .
    GeneIDi 12387806.
    KEGGi ctf:CTDLC_0322.
    PATRICi 42818551. VBIChlTra159408_0346.

    Phylogenomic databases

    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi GTEMCMP.

    Enzyme and pathway databases

    BioCyci CTRA759364:GLAV-331-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract."
      Sturdevant G.L., Kari L., Gardner D.J., Olivares-Zavaleta N., Randall L.B., Whitmire W.M., Carlson J.H., Goheen M.M., Selleck E.M., Martens C., Caldwell H.D.
      Infect. Immun. 78:3660-3668(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D-LCImported.

    Entry informationi

    Entry nameiD7DGR8_CHLTL
    AccessioniPrimary (citable) accession number: D7DGR8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3