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D7DDE3

- D7DDE3_CHLTD

UniProt

D7DDE3 - D7DDE3_CHLTD

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Protein

Elongation factor Tu

Gene

tuf

Organism
Chlamydia trachomatis serovar D (strain D-EC)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPUniRule annotation
Nucleotide bindingi86 – 905GTPUniRule annotation
Nucleotide bindingi141 – 1444GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTRA759363:GLAU-331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotationImported
Ordered Locus Names:CTDEC_0322Imported
OrganismiChlamydia trachomatis serovar D (strain D-EC)Imported
Taxonomic identifieri759363 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000381: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD7DDE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229290.
KOiK02358.
OMAiGTEMCMP.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7DDE3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIFEMSKET FQRNKPHINI GTIGHVDHGK TTLTAAITRA LSGDGLADFR
60 70 80 90 100
DYSSIDNTPE EKARGITINA SHVEYETANR HYAHVDCPGH ADYVKNMITG
110 120 130 140 150
AAQMDGAILV VSATDGAMPQ TKEHILLARQ VGVPYIVVFL NKIDMISEED
160 170 180 190 200
AELVDLVEME LVELLEEKGY KGCPIIRGSA LKALEGDAAY IEKVRELMQA
210 220 230 240 250
VDDNIPTPER EIDKPFLMPI EDVFSISGRG TVVTGRIERG IVKVSDKVQL
260 270 280 290 300
VGLRDTKETI VTGVEMFRKE LPEGRAGENV GLLLRGIGKN DVERGMVVCL
310 320 330 340 350
PNSVKPHTQF KCAVYVLQKE EGGRHKPFFT GYRPQFFFRT TDVTGVVTLP
360 370 380 390
EGIEMVMPGD NVEFEVQLIS PVALEEGMRF AIREGGRTIG AGTISKIIA
Length:399
Mass (Da):43,969
Last modified:August 10, 2010 - v1
Checksum:iB507303F29FB2A98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002052 Genomic DNA. Translation: ADI50997.1.
RefSeqiYP_005811374.1. NC_017434.1.

Genome annotation databases

EnsemblBacteriaiADI50997; ADI50997; CTDEC_0322.
GeneIDi12386954.
KEGGictd:CTDEC_0322.
PATRICi42816519. VBIChlTra153166_0347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002052 Genomic DNA. Translation: ADI50997.1 .
RefSeqi YP_005811374.1. NC_017434.1.

3D structure databases

ProteinModelPortali D7DDE3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI50997 ; ADI50997 ; CTDEC_0322 .
GeneIDi 12386954.
KEGGi ctd:CTDEC_0322.
PATRICi 42816519. VBIChlTra153166_0347.

Phylogenomic databases

HOGENOMi HOG000229290.
KOi K02358.
OMAi GTEMCMP.

Enzyme and pathway databases

BioCyci CTRA759363:GLAU-331-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. EFACTOR_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract."
    Sturdevant G.L., Kari L., Gardner D.J., Olivares-Zavaleta N., Randall L.B., Whitmire W.M., Carlson J.H., Goheen M.M., Selleck E.M., Martens C., Caldwell H.D.
    Infect. Immun. 78:3660-3668(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D-ECImported.

Entry informationi

Entry nameiD7DDE3_CHLTD
AccessioniPrimary (citable) accession number: D7DDE3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3