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D7DDE3

- D7DDE3_CHLTD

UniProt

D7DDE3 - D7DDE3_CHLTD

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Protein
Elongation factor Tu
Gene
tuf, CTDEC_0322
Organism
Chlamydia trachomatis serovar D (strain D-EC)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTP By similarityUniRule annotation
Nucleotide bindingi86 – 905GTP By similarityUniRule annotation
Nucleotide bindingi141 – 1444GTP By similarityUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTRA759363:GLAU-331-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotationImported
    Ordered Locus Names:CTDEC_0322Imported
    OrganismiChlamydia trachomatis serovar D (strain D-EC)Imported
    Taxonomic identifieri759363 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000381: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer By similarity.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD7DDE3.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiGTEMCMP.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7DDE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIFEMSKET FQRNKPHINI GTIGHVDHGK TTLTAAITRA LSGDGLADFR    50
    DYSSIDNTPE EKARGITINA SHVEYETANR HYAHVDCPGH ADYVKNMITG 100
    AAQMDGAILV VSATDGAMPQ TKEHILLARQ VGVPYIVVFL NKIDMISEED 150
    AELVDLVEME LVELLEEKGY KGCPIIRGSA LKALEGDAAY IEKVRELMQA 200
    VDDNIPTPER EIDKPFLMPI EDVFSISGRG TVVTGRIERG IVKVSDKVQL 250
    VGLRDTKETI VTGVEMFRKE LPEGRAGENV GLLLRGIGKN DVERGMVVCL 300
    PNSVKPHTQF KCAVYVLQKE EGGRHKPFFT GYRPQFFFRT TDVTGVVTLP 350
    EGIEMVMPGD NVEFEVQLIS PVALEEGMRF AIREGGRTIG AGTISKIIA 399
    Length:399
    Mass (Da):43,969
    Last modified:August 10, 2010 - v1
    Checksum:iB507303F29FB2A98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002052 Genomic DNA. Translation: ADI50997.1.
    RefSeqiYP_005811374.1. NC_017434.1.

    Genome annotation databases

    EnsemblBacteriaiADI50997; ADI50997; CTDEC_0322.
    GeneIDi12386954.
    KEGGictd:CTDEC_0322.
    PATRICi42816519. VBIChlTra153166_0347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002052 Genomic DNA. Translation: ADI50997.1 .
    RefSeqi YP_005811374.1. NC_017434.1.

    3D structure databases

    ProteinModelPortali D7DDE3.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI50997 ; ADI50997 ; CTDEC_0322 .
    GeneIDi 12386954.
    KEGGi ctd:CTDEC_0322.
    PATRICi 42816519. VBIChlTra153166_0347.

    Phylogenomic databases

    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi GTEMCMP.

    Enzyme and pathway databases

    BioCyci CTRA759363:GLAU-331-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract."
      Sturdevant G.L., Kari L., Gardner D.J., Olivares-Zavaleta N., Randall L.B., Whitmire W.M., Carlson J.H., Goheen M.M., Selleck E.M., Martens C., Caldwell H.D.
      Infect. Immun. 78:3660-3668(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D-ECImported.

    Entry informationi

    Entry nameiD7DDE3_CHLTD
    AccessioniPrimary (citable) accession number: D7DDE3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: June 11, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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